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| butizide Basic information |
| butizide Chemical Properties |
Melting point | 214-217°C | Boiling point | 562.7±60.0 °C(Predicted) | density | 1.4221 (rough estimate) | refractive index | 1.6100 (estimate) | storage temp. | Refrigerator | solubility | DMSO (Slightly), Methanol (Slightly) | form | Solid | pka | 9.01±0.40(Predicted) | color | White to Yellow |
| butizide Usage And Synthesis |
Chemical Properties | Off-White Solid | Originator | Saltucin,Boehringer Mannheim,W. Germany,1961 | Uses | Diuretic and antihypertensive. | Definition | ChEBI: Butizide is a benzothiadiazine. | Manufacturing Process | Chlorsulfonic acid and 3-chloroaniline react to give an intermediate which
when treated with ammonia yields 5-chloro-2,4-disulfamylaniline. 20 g of 5-chloro-2,4-disulfamylaniline in 15 cc of diethyleneglycol-dimethyl
ether with 0.9 g of isovaleraldehyde are reacted in the presence of 0.5 cc of a
saturated solution of hydrochloric acid in ethyl acetate at 80°-90°C. The
reaction mixture is concentrated under reduced pressure, an oily product
precipitates on the addition of water, the latter is decanted and ethanol added
to the remaining oil. 3-Isobutyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-
benzothiadiazine-1,1-dioxide crystallizes and, after recrystallization from
dimethylformamide and water, melts at 241°-245°C. | Therapeutic Function | Diuretic, Antihypertensive |
| butizide Preparation Products And Raw materials |
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