butizide

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Products Intro: Product Name:Buthiazide
CAS:2043-38-1
Package:2.5g,250Mg
Company Name: Chemsky(shanghai)International Co.,Ltd.  
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Products Intro: Product Name:Buthiazide
CAS:2043-38-1
Purity:98%
Company Name: Cato Research Chemicals Inc.  
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Products Intro: Product Name:Buthiazide
CAS:2043-38-1
Purity:95% Package:25Mg, 50Mg
Company Name: Shenzhen Polymeri Biochemical Technology Co., Ltd.  
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Products Intro: Product Name:Buthiazide
CAS:2043-38-1
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Products Intro: Product Name:Buthiazide
CAS:2043-38-1
butizide Basic information
Product Name:butizide
Synonyms:6-chloro-3,4-dihydro-3-isobutyl-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide;butizide;Buthiazide;Thiabutazide;Eunephran;S-3500;Saltucin;Su-6187
CAS:2043-38-1
MF:C11H16ClN3O4S2
MW:353.85
EINECS:218-048-8
Product Categories:Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:2043-38-1.mol
butizide Structure
butizide Chemical Properties
Melting point 214-217°C
Boiling point 562.7±60.0 °C(Predicted)
density 1.4221 (rough estimate)
refractive index 1.6100 (estimate)
storage temp. Refrigerator
pka9.01±0.40(Predicted)
Safety Information
MSDS Information
butizide Usage And Synthesis
Chemical PropertiesOff-White Solid
OriginatorSaltucin,Boehringer Mannheim,W. Germany,1961
UsesDiuretic and antihypertensive.
Manufacturing ProcessChlorsulfonic acid and 3-chloroaniline react to give an intermediate which when treated with ammonia yields 5-chloro-2,4-disulfamylaniline.
20 g of 5-chloro-2,4-disulfamylaniline in 15 cc of diethyleneglycol-dimethyl ether with 0.9 g of isovaleraldehyde are reacted in the presence of 0.5 cc of a saturated solution of hydrochloric acid in ethyl acetate at 80°-90°C. The reaction mixture is concentrated under reduced pressure, an oily product precipitates on the addition of water, the latter is decanted and ethanol added to the remaining oil. 3-Isobutyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4- benzothiadiazine-1,1-dioxide crystallizes and, after recrystallization from dimethylformamide and water, melts at 241°-245°C.
Therapeutic FunctionDiuretic, Antihypertensive
butizide Preparation Products And Raw materials
Raw materialsAmmonia-->3-Chloroaniline-->Chlorosulfonic acid-->Isovaleraldehyde
Tag:butizide(2043-38-1) Related Product Information
Propantheline bromide mebutizide butizide CYCLOTHIAZIDE Cyclopenthiazide 2-AMINO-N-BUTYLBENZENESULFONAMIDE Hydrochlorothiazide ethiazide 2-amino-N-propylbenzenesulfonamide