PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL manufacturers
|
| | PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL Basic information |
| Product Name: | PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL | | Synonyms: | PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL;PIPERAZINE-1-CARBOXYLIC ACID AMIDE HYDROCHLORIDE;BUTTPARK 85\04-05;PIPERAZINE-1-CARBOXYLIC ACID AMIDE X HCL;Piperazine-1-carboxamide hydrochloride;1-piperazinecarboxamide hydrochloride;PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL ISO 9001：2015 REACH;Piperazine-1-carboxylic acid amid | | CAS: | 474711-89-2 | | MF: | C5H12ClN3O | | MW: | 165.62 | | EINECS: | | | Product Categories: | piperazines | | Mol File: | 474711-89-2.mol |  |
| | PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL Chemical Properties |
| Melting point | 221-224°C | | storage temp. | Inert atmosphere,Room Temperature | | Appearance | White to off-white Solid | | InChI | InChI=1S/C5H11N3O.ClH/c6-5(9)8-3-1-7-2-4-8;/h7H,1-4H2,(H2,6,9);1H | | InChIKey | UVYKKFKLOUEFAR-UHFFFAOYSA-N | | SMILES | C(N1CCNCC1)(=O)N.Cl |
| Hazard Codes | Xi | | Risk Statements | 36 | | Safety Statements | 26 | | HazardClass | IRRITANT | | HS Code | 2933399990 |
| | PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL Usage And Synthesis |
| Uses | Piperazine-1-carboxamide Hydrochloride is used in preparation of heteroaromatic derivatives as PDE4 inhibitors. | | Synthesis | General procedure for the synthesis of piperazine-1-amide hydrochloride from tert-butyl 4-carbamoylpiperazine-1-carboxylate: To a dichloromethane (DCM, 2 mL) solution of tert-butyl 4-carbamoylpiperazine-1-carboxylate (0.16 g, 0.7 mmol) was added an ethyl acetate (EtOAc) solution of hydrochloric acid (4 M, 2 mL). The reaction mixture was stirred at room temperature for 30 min and then concentrated under reduced pressure to give piperazine-1-amide hydrochloride as a white solid (0.16 g, 100% yield). The product was characterized by 1H NMR (600 MHz, CD3OD): δ 3.71-3.73 (m, 4H), 3.25-3.27 (m, 4H); MS-ESI: m/z 130.10 [M + H - HCl]+. | | References | [1] Patent: WO2016/34134, 2016, A1. Location in patent: Paragraph 00403
[2] Patent: CN105399698, 2016, A. Location in patent: Paragraph 1050; 1054-1056
[3] Patent: EP1593679, 2005, A1. Location in patent: Page/Page column 59 |
| | PIPERAZINE-1-CARBOXYLIC ACID AMIDE HCL Preparation Products And Raw materials |
|