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Vecuronium bromide

Vecuronium bromide Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-66670886
Email: info@dakenchem.com
Products Intro: Product Name:Vecuronium bromide
CAS:50700-72-6
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd
Tel: 010-60279497
Email: sales01@cooperate-pharm.com
Products Intro: Product Name:Vecuronium bromide
CAS:50700-72-6
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:50700-72-6
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: career henan chemical co
Tel: +86-371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:Vecuronium bromide
CAS:50700-72-6
Purity:98% Package:1KG;1USD
Company Name: Hebei Guanlang Biotechnology Co., Ltd.
Tel:
Email: sales3@crovellbio.com
Products Intro: Product Name:Vecuronium bromide
CAS:50700-72-6
Purity:99%min Package:25KG;100USD

Lastest Price from Vecuronium bromide manufacturers

  • Vecuronium Bromide
  • US $10.00 / Kg/Drum
  • 2021-08-26
  • CAS:50700-72-6
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 10 ton
  • Vecuronium bromide
  • US $11000.00 / Kg/Bag
  • 2021-07-13
  • CAS:50700-72-6
  • Min. Order: 20g
  • Purity: 99%-101%
  • Supply Ability: 100kg/month
  • Vecuronium bromide
  • US $15.00-10.00 / KG
  • 2021-07-13
  • CAS:50700-72-6
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
Vecuronium bromide Basic information
Description References
Product Name:Vecuronium bromide
Synonyms:norcuron;[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetoxy-10,13-dimethyl-16-(1-methylpiperidin-1-ium-1-yl)-2-(1-piperidyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate;1-[(2Beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methylpiperidinium bromide hydrate;1-(3-alpha,17-beta-diacetoxy-2-beta-piperidino-5-alpha-androstan-piperidiniu;17beta-diol,16beta-pipecolinio-2beta-piperidino-5alpha-androstan-3alphbro;mide,diacetate;nc-45;orgnc45
CAS:50700-72-6
MF:C34H57BrN2O4
MW:637.73138
EINECS:256-723-9
Product Categories:CAMPRAL;API;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;Pharmaceutical material and intermeidates;Organics;Neuromuscular blocking agent;Steroids;Acetylcholine receptor;APIs
Mol File:50700-72-6.mol
Vecuronium bromide Structure
Vecuronium bromide Chemical Properties
Melting point 227-229°C
alpha +30.5~+35.0゜(D/20℃)(c=0.5,dil.HCl)
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility Slightly soluble in water, freely soluble in methylene chloride, sparingly soluble in acetonitrile and in anhydrous ethanol.
form neat
Merck 14,9941
BRN 4837308
InChIKeyVEPSYABRBFXYIB-PWXDFCLTSA-M
CAS DataBase Reference50700-72-6(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-22
Safety Statements 26-37/39
WGK Germany 3
RTECS TN4875000
HS Code 2933399090
ToxicityLD50 in mice: 0.061 mg/kg i.v. (Buckett)
Vecuronium bromide Usage And Synthesis
DescriptionVecuronium bromide (Brand name: Norcuron) is a drug which can be supplied to general anesthesia to keep skeletal muscle relaxation during the surgery or mechanical ventilation. It can also be used to help with endotracheal intubation. It has rapid onset (within 4 minutes) and has its effect last for 4 hour. Its mechanism of action is through competitively binding to the nicotinic cholinergic receptors, further antagonizing the opportunity for acetylcholine from binding to the nicotinic receptor at the postjunctional membrane of the myoneural junction. This process prevents the depolarization and the release of calcium ions, stopping muscle contraction and help muscle relaxation.
Referenceshttps://en.wikipedia.org/wiki/Vecuronium_bromide
https://www.drugbank.ca/drugs/DB01339  
DescriptionVecuronium, 1-[(2β,3α,5α,16β,17β,)-3,17-bis(acetyloxy)-2-(1-piperidinyl) androstan-16-yl]-1-methylpiperidinium bromide (15.1.9), differs from panuronium only in the extent of alkylation. Only the piperidine substituent on C16 of the steroid skeleton is transformed into a quaternary salt.
Chemical PropertiesWhite Solid
Usesalcohol antagonist
UsesAn aminosteroid, competitive neuromuscular blocker agent.
DefinitionChEBI: The organic bromide salt of a 5alpha-androstane compound having 3alpha-acetoxy-, 17beta-acetoxy-, 2beta-piperidinino- and 16beta-N-methylpiperidinium su stituents.
Brand nameNorcuron (Organon).
Biological FunctionsVecuronium bromide (Norcuron) is chemically identical to pancuronium except for a tertiary amine in place of a quaternary nitrogen. However, some of the drug will exist as the bisquaternary compound, depending on body pH. Vecuronium has a moderate onset of action (2.4 minutes) and a duration of effect of about 50 minutes. Like pancuronium, it does not block ganglia or vagal neuroeffector junctions, does not release histamine, and is eliminated by urinary excretion.
General DescriptionVecuronium bromide, 1-(3 ,17 -dihydroxy-2 -piperidino-5 -androstan-16 -yl)-1-methylpiperidinium bromide diacetate (Norcuron), is themonoquaternary analog of pancuronium bromide. It belongsto the class of nondepolarizing neuromuscular blockingagents and produces effects similar to those of drugs in thisclass. It is unstable in the presence of acids and undergoesgradual hydrolysis of its ester functions in aqueous solution.Aqueous solutions have a pH of about 4.0.
Clinical UseVecuronium Bromide is usedmainly to produce skeletal muscle relaxation during surgeryand to assist in controlled respiration after general anesthesiahas been induced.
Veterinary Drugs and TreatmentsVecuronium is indicated as an adjunct to general anesthesia to produce muscle relaxation during surgical procedures or mechanical ventilation and to facilitate endotracheal intubation. It causes very minimal cardiac effects and generally does not cause the release of histamine.
Vecuronium bromide Preparation Products And Raw materials
Raw materialsMethyl bromide-->Pancuronium bromide
Tag:Vecuronium bromide(50700-72-6) Related Product Information
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