PJ-34
中文名称 | PJ-34 |
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中文同义词 | N-(6-氧代-5,6-二氢菲啶-2-基)-2-(N,N-二甲基氨基)乙酰胺;PJ34(游离);2-(二甲基氨基)-N-(6-氧代-5,6-二氢菲啶-2-基)乙酰胺;化合物PJ34;2-(二甲氨基)-N-(6-氧代-5,6-二氢菲-2-基)乙酰胺;PJ34,PARPL/2 抑制剂 |
英文名称 | PJ-34 |
英文同义词 | N,N-Dimethyl-2-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide;N-(6-OXO-5,6-DIHYDRO-PHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HCL;N-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HYDROCHLORIDE;PJ-34;PJ34(free base);Acetamide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-;N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide PJ 34;N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide |
CAS号 | 344458-19-1 |
分子式 | C17H17N3O2 |
分子量 | 295.34 |
EINECS号 | 604-604-1 |
相关类别 | 小分子抑制剂,天然产物;DNA损伤;Inhibitors |
Mol文件 | Mol File |
结构式 |
PJ-34 性质
储存条件 | Sealed in dry,Store in freezer, under -20°C |
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溶解度 | 溶于二甲基亚砜 |
PARP 110 nM (IC 50 ) |
PARP-2 86 nM (IC 50 ) |
PARP-1 110 nM (IC 50 ) |
PJ34 inhibits the PARP enzyme activity with an IC 50 of 110±1.9 nM. To compare the neuroprotective properties of other PARP inhibitors in PC12 cells, PJ34 is evaluated using by LDH assay. PJ34 treatment also significantly and concentration dependently attenuates cell death at a concentration ranging from 10 -7 to 10 -5 M.
To compare the potency and efficacy with other PARP inhibitors, PJ34 is evaluated at the doses of 3.2 and 10 mg/kg, respectively. PJ34 at the dose of 3.2 mg/kg significantly reduces cortical damage by 33%; however, 10 mg/kg dosing shows reversed effect (17% reduction). PJ34 (25 mg/kg) reduces the levels of TNF-α mRNA in ischemic animals by 70% and these values in treated mice do not differ from that of sham or naive animals. Treatment of ischemic mice with PJ34 reduces the level of E-selectin mRNA by 81% and that of ICAM-1 mRNA by 54%, compared to vehicle-treated ischemic mice.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-13688A | PJ34 | 5 mg | 356元 | |
2024/01/25 | HY-13688A | PJ-34 PJ34 | 344458-19-1 | 10mg | 570元 |