- Selpercatinib
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- $80.00 / 1kg
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2024-04-28
- CAS:2152628-33-4
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 1000
- LOXO-292
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- $50.00 / 1KG
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2024-04-28
- CAS:2152628-33-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500
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| | LOXO-292 Basic information |
| Product Name: | LOXO-292 | | Synonyms: | CPD2206;LOXO-292; LOXO292;LOXO 292;LOXO-292,Selpercatinib;Selpercatinib(LOXO-292);6-?(2-?Hydroxy-?2-?methylpropoxy)?-?4-?[6-?[6-?[(6-?methoxy-?3-?pyridinyl)?methyl]?-?3,?6-?diazabicyclo[3.1.1]?hept-?3-?yl]?-?3-?pyridinyl]?pyrazolo[1,?5-?a]?pyridine-?3-?carbonitrile;Pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]hept-3-yl]-3-pyridinyl]-;LOXO-292 USP/EP/BP;6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxypyridin-3-yl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]pyridin-3-yl]pyrazolo[1,5-a]pyridine-3-carbonitrile | | CAS: | 2152628-33-4 | | MF: | C29H31N7O3 | | MW: | 525.6 | | EINECS: | 207-854-9 | | Product Categories: | GS;API;2152628-33-4 | | Mol File: | 2152628-33-4.mol |  |
| | LOXO-292 Chemical Properties |
| density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:20.0(Max Conc. mg/mL);38.05(Max Conc. mM) | | form | A crystalline solid | | pka | 14.00±0.29(Predicted) | | InChIKey | XIIOFHFUYBLOLW-UHFFFAOYSA-N | | SMILES | C12=C(C#N)C=NN1C=C(OCC(O)(C)C)C=C2C1=CC=C(N2CC3CC(N3CC3=CC=C(OC)N=C3)C2)N=C1 |
| | LOXO-292 Usage And Synthesis |
| Uses | Selpercatinib is a highly selective, potent RET inhibitor, an oral drug used to treat cancers in people whose tumours have been altered (mutated or fused) in specific genes (RET stands for "rearrangement during transfection"). | | Side effects | Selpercatinib can cause serious side effects including liver toxicity, high blood pressure, heart rhythm changes due to prolongation of heart electrical activity (QT prolongation), bleeding, allergic reactions, impaired wound healing and harm to an unborn baby.
Selpercatinib may cause harm to a developing fetus or a newborn baby. | | storage | Store at -20°C | | Dosage | The recommended selpercatinib dose based on body weight is:
(1) Less than 50 kg: 120 mg orally twice daily
(2) 50 kg or greater: 160 mg orally twice daily
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| | LOXO-292 Preparation Products And Raw materials |
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