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| paraflutizide Basic information |
Product Name: | paraflutizide | Synonyms: | paraflutizide;6-Chloro-3-(p-fluorobenzyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;LD-3612;6-chloro-3-(4-fluorobenzyl)-1,1-diketo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide;6-chloro-3-[(4-fluorophenyl)methyl]-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide;2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[(4-fluorophenyl)methyl]-3,4-dihydro-, 1,1-dioxide;Paraflutizida | CAS: | 1580-83-2 | MF: | C14H13ClFN3O4S2 | MW: | 405.85 | EINECS: | 2164267 | Product Categories: | | Mol File: | 1580-83-2.mol | |
| paraflutizide Chemical Properties |
Melting point | 238-240° | Boiling point | 636.2±65.0 °C(Predicted) | density | 1.571±0.06 g/cm3(Predicted) | pka | 8.66±0.40(Predicted) |
Toxicity | LD50 oral in mouse: > 10gm/kg |
| paraflutizide Usage And Synthesis |
Originator | Paraflutizide, Shanghai Lansheng | Manufacturing Process | A mixture of 5.0 g (0.0357 g/mol) of ρ-fluorophenylethyl alcohol, 2.0 g (0.007 g/mol) of 5-chloro-2,4-disulphamylaniline, 2.0 g (0.0068 g/mol) of potassium bichromate and 15 ml of concentrated hydrochloric acid (0.176 g/mol) and 25 ml of water is heated under reflux for 1 h. The mixture is allowed to cool, and 15 ml of ether are added to separate the excess of ρ-fluorophenylethyl alcohol. The aqueous layer is decanted and frozen for 2 h and the precipitate is separated, washed with water and dried in vacuum over phosphoric anhydride. There are collected 1.35 g (yield 47.5%) of the 1,1-dioxide of 3-ρfluorophenyl-methyl-7-sulphamyl-6-chloro-3,4-dihydrobenzo-1,2,4-thiadiazine, which when recrystallised from 30 ml of 50% alcohol on "Norit" active carbon takes the form of a white crystalline substance, melting point is 239°C. | Therapeutic Function | Diuretic |
| paraflutizide Preparation Products And Raw materials |
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