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Metapramine

Metapramine Suppliers list
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695
Email: laboratory@coreychem.com
Products Intro: Product Name:Metapramine
CAS:21730-16-5
Purity:95%~99.99% Package:1KG;2.8USD
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Products Intro: Product Name:Metapramine
CAS:21730-16-5
Purity:99.9% Package:1g;1.1USD Remarks:FDA GMP CEP Approved Manufacturer
Company Name: J & K SCIENTIFIC LTD.  
Tel: 010-82848833 400-666-7788
Email: jkinfo@jkchemical.com
Products Intro: Product Name:MetapraMine
CAS:21730-16-5
Package:100Mg,10Mg
Company Name: Chemsky (shanghai) International Co.,Ltd  
Tel: 021-50135380
Email: shchemsky@sina.com
Products Intro: Product Name:MetapraMine;10,11-Dihydro-N,5-diMethyl-5H-Dibenz[b,f]azepin-10-aMine; 5-Methyl-10-MethylaMino-10,11-dihydrodibenzo[b,f]azepine; MetapraMine; RP 19560; 10,11-Dihydro-5-Methyl-10-5H-Dibenz[b,f]azepine
CAS:21730-16-5
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
Company Name: BOC Sciences  
Tel: 16314854226
Email: info@bocsci.com
Products Intro: Product Name:Metapramine
CAS:21730-16-5
Purity:95%

Metapramine manufacturers

  • Metapramine USP/EP/BP
  • Metapramine USP/EP/BP pictures
  • $1.10 / 1g
  • 2021-07-27
  • CAS:21730-16-5
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons min
Metapramine Basic information
Product Name:Metapramine
Synonyms:Metapramine;10,11-Dihydro-5-methyl-10-(methylamino)-5H-dibenz[b,f]azepine;10,11-Dihydro-5-Methyl-10-5H-Dibenz[b,f]azepine;10,11-Dihydro-N,5-diMethyl-5H-Dibenz[b,f]azepin-10-aMine;5-Methyl-10-MethylaMino-10,11-dihydrodibenzo[b,f]azepine;RP 19560;5H-Dibenz[b,f]azepin-10-amine, 10,11-dihydro-N,5-dimethyl-;Metapramine USP/EP/BP
CAS:21730-16-5
MF:C16H18N2
MW:238.33
EINECS:
Product Categories:Aromatics;Heterocycles;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals
Mol File:21730-16-5.mol
Metapramine Structure
Metapramine Chemical Properties
Melting point 237-240 °C
Boiling point 350.8±42.0 °C(Predicted)
density 1.12±0.1 g/cm3(Predicted)
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
form Oil
pka9.09±0.20(Predicted)
color Colourless to Pale Yellow
Stability:Hygroscopic
Safety Information
MSDS Information
Metapramine Usage And Synthesis
DescriptionMetapramine is an antidepressant with a pharmacological profile similar to the tricyclics and an apparent rapid clinical onset of action. Metapramine differs biochemically from the tricyclics in that it markedly enhances norepinephrine turnover with minimal inhibition of reuptake. Like the tricyclics, however, it does down regulate β-receptors.
OriginatorRhone-Poulenc (France)
UsesMetapramine is a tricyclic antidepressant derived from dibenzoazepine. Metapramine acts as a norepinephrine reuptake inhibitor without affecting the reuptake of serotonin or dopamine.
DefinitionChEBI: Metapramine is a dibenzooxazepine.
Manufacturing Process5-Methyl-dibenzo[b,f]azepine (4.1 g), N-diethylaminoborane (1.7 g) and freshly distilled toluene (150 cc) are introduced into a 500 cc three-neck flask equipped with a dropping funnel and a condenser, and protected against moisture by a calcium chloride guard tube. The solution is heated under reflux (110°C) for 22 hours under a nitrogen atmosphere and then cooled. A 2 N aqueous sodium hydroxide solution (33 cc) is then run in followed by an 0.316 N aqueous methylchloramine solution (190 cc), the addition of which takes 9 minutes. The mixture is stirred for 1 hour and then decanted. The organic layer is washed with water until it has a pH of 6 and is then extracted with 2 N hydrochloric acid (5 times 50 cc), dried over sodium sulfate, filtered and evaporated. Recrystallization of the residue from petroleum ether yields some unconverted 5-methyl-dibenzo[b,f]azepine (2.17 g).
The aqueous acid solution is rendered alkaline by adding 2 N sodium hydroxide solution. After extracting with diethyl ether (3 times 100 cc), drying the extracts over potassium carbonate, treating them with decolorizing charcoal, filtering and evaporating the ether, a yellowish oil (0.9 g), identified as 5-methyl-10-methylamino-10,11-dihydrodibenzo[b,f]azepine, is obtained in a yield of 37.5%.
Methylchloramine can be prepared by adding an aqueous solution of sodium hypochlorite to an aqueous solution of methylamine in accordance with the process described by W.S. Metcalf, J. Chem. Soc.1942,148.
Brand nameTIMAXEL
Therapeutic FunctionAntidepressant
Metapramine Preparation Products And Raw materials
Raw materialsMethylamine-->Sodium hypochlorite
Tag:Metapramine(21730-16-5) Related Product Information
DESIPRAMINE Metapramine