美托拉宗

美托拉宗

中文名称美托拉宗
中文同义词7-氯-1,2,3,4-四氢-2-甲基-3-(2-甲基苯基)-4-氧代-6-喹唑磺酰胺;美托拉宗;美托拉宗(标准品);米托拉腙;甲醋唑胺;美托拉腙;美托拉宗杂质;美托拉索 EP标准品
英文名称Metolazone
英文同义词s720-22;7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide, SR-720-22, Diulo, Metenix, Mykrox, Oldren,;6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo- (9CI);6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl- (8CI);Normelan;Xuret;6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro- 2-methyl-3-(2-methylphenyl)-4-oxo-;METAZOLINE
CAS号17560-51-9
分子式C16H16ClN3O3S
分子量365.83
EINECS号241-539-3
相关类别中间体;小分子抑制剂;科研试剂;利尿药物;原料;医药原料;Organics;Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Aromatics;Heterocycles;Sulfur & Selenium Compounds;ZAROXOLYN;Other APIs;有机化工原料
Mol文件17560-51-9.mol
结构式美托拉宗 结构式

美托拉宗 性质

熔点252-254°C
沸点613.6±65.0 °C(Predicted)
密度1.2895 (rough estimate)
折射率1.6100 (estimate)
储存条件2-8°C
溶解度二甲基亚砜:>5mg/mL
酸度系数(pKa)pKa 9.7 (Uncertain)
形态固体
颜色白色
水溶解性60.3mg/L(25 ºC)
稳定性自购买之日起 2 年内保持稳定。 DMSO 中的溶液可在 -20°C 下干燥保存长达 2 个月。
InChIKeyAQCHWTWZEMGIFD-UHFFFAOYSA-N
CAS 数据库17560-51-9(CAS DataBase Reference)
NIST化学物质信息Metolazone(17560-51-9)

美托拉宗 用途与合成方法

Metolazone (SR 720-22)是一种利尿剂,主要用于治疗充血性心脏衰竭和高血压。

Metolazone (SR-720-22) is a thiazide-like diuretic marketed under the brand names Zytanix from Zydus Cadila, Zaroxolyn, and Mykrox. It is primarily used to treat congestive heart failure and high blood pressure. Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases. This lowers blood pressure and prevents excess fluid accumulation in heart failure. Metolazone is sometimes used together with loop diuretics such as furosemide or bumetanide, but these highly effective combinations can lead to dehydration and electrolyte abnormalities. Metolazone and the other thiazide diuretics inhibit the function of the sodium-chloride symporter, preventing sodium and chloride, and therefore water too, from leaving the lumen to enter the tubule cell. As a result, water remains in the lumen and is excreted as urine, instead of being reabsorbed into the bloodstream. Since most of the sodium in the lumen has already been reabsorbed by the time the filtrate reaches the distal convoluted tubule, thiazide diuretics have limited effects on water balance and on electrolyte levels. Nevertheless, they can be associated with low sodium levels, volume depletion, and low blood pressure, among other adverse effects.

用途 
利尿药。

安全信息

WGK Germany2
RTECS号VA1700000
海关编码2935904000
毒害物质数据17560-51-9(Hazardous Substances Data)
毒性LD50 in mice (mg/kg): >5000 orally; >1500 i.p. (Shetty, 1967)

MSDS信息

提供商 语言
英文
更新日期产品编号产品名称CAS号包装价格
2024/01/25HY-B0209美托拉宗
Metolazone
17560-51-950mg600元
2024/01/25HY-B0209美托拉宗
Metolazone
17560-51-910mM * 1mLin DMSO660元

美托拉宗 上下游产品信息

上游原料
"美托拉宗"相关产品信息
甲基硫菌灵 5-甲基苯并三氮唑 结晶磺胺 醚菌酯 甲基三苯基溴化膦 尼泊金甲酯 甲基磺酰胺 对甲苯磺酰胺 苄嘧磺隆 甲磺隆 甲基苯基二氯硅烷 水杨酸甲酯 一氯二氟甲烷 甲基对硫磷 溴甲烷 海米那 3-氨甲基苯磺酰胺 邻氯苯磺酰胺
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 | 评选活动 | HS海关编码 | MSDS查询 | 化工站点

Copyright © 2016-2023 ChemicalBook 版权所有  京ICP备07040585号  京公海网安备11010802032676号  

互联网增值电信业务经营许可证:京ICP证150597号  互联网药品信息服务资格证编号(京)-非经营性-2015-0073  信息系统安全等级保护备案证明(三级)  营业执照公示

根据相关法律法规和本站规定,单位或个人购买相关危险物品应取得有效的资质、资格条件。
参考《应急管理部等多部门关于加强互联网销售危险化学品安全管理的通知 (应急〔2022〕119号)》《互联网危险物品信息发布管理规定》