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Cerivastatin sodium

Cerivastatin sodium Suppliers list
Company Name: Guangzhou PI PI Biotech Inc
Tel: ;
Email: sales@pipitech.com;87478684@qq.com
Products Intro: Product Name:Cerivastatin Sodium
CAS:143201-11-0
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:(3R,5S,6E)-7-[4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic Acid Sodium
Company Name: BOC Sciences
Tel: 1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:Cerivastatin Sodium Salt
CAS:143201-11-0
Purity:>95%
Company Name: HENAN BON INDUSTRIAL CO.,LTD
Tel: 0371-55170695
Email: info@hnbon.com
Products Intro: CAS:143201-11-0
Purity:0.99 Package:25KG;5KG;1KG;500G
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: 86-18523575427
Email: sales@conier.com
Products Intro: Product Name:cerivastatin sodium
CAS:143201-11-0
Purity:0.99 Package:1kg
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel:
Email: 1015@dideu.com
Products Intro: Product Name:Cerivastatin sodium
CAS:143201-11-0
Purity:99.0% Package:1KG;USD|25KG;USD

Lastest Price from Cerivastatin sodium manufacturers

  • Cerivastatin sodium
  • US $0.00-0.00 / KG
  • 2020-05-12
  • CAS:143201-11-0
  • Min. Order: 1KG
  • Purity: 99.0%
  • Supply Ability: 500 MT
Cerivastatin sodium Basic information
Product Name:Cerivastatin sodium
Synonyms:BAYCOL;6-Heptenoic acid, 7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-, monosodium salt, (3R,5S,6E)-;6-Heptenoic acid, 7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-, monosodium salt, [S-[R*,S*-(E)]]-;BAY-w 6228;Cerivastatin sodium;Sodium 7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-dipropan-2-yl-pyrid in-3-yl]-3,5-dihydroxy-hept-6-enoate;Rivastatin, Baycol, Lipobay;(3R,5S,6E)-7-[4-(4-Fluorophenyl)-5-(MethoxyMethyl)-2,6-bis(1-Methylethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic Acid SodiuM Salt
CAS:143201-11-0
MF:C26H34FNO5
MW:459.55
EINECS:
Product Categories:Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:143201-11-0.mol
Cerivastatin sodium Structure
Cerivastatin sodium Chemical Properties
Melting point 197-199°C
alpha D20 +24.1° (c = 1 in ethanol)
storage temp. Hygroscopic, Store under Inert atmosphere -20°C Freezer
solubility H2O: ≥5mg/mL
form powder
color white to tan
optical activity[α]/D +18 to +26° in ethanol
CAS DataBase Reference143201-11-0(CAS DataBase Reference)
Safety Information
WGK Germany 3
MSDS Information
Cerivastatin sodium Usage And Synthesis
DescriptionLipobay was launched in Denmark, Germany and the UK for treatment of primary hypercholesteremia types Ⅱa and Ⅱb. It is available through a nine step synthesis beginning with the Hantsch reaction of ethyl 3-amino-4-methylpent-2-enoate and 4-(ethoxycarbonyl)-5-(4-fluorophenyl)-2-methylpent-4-en-3-one. Lipobay acts as an HMG-CoA reductase inhibitor showing a high liver selectivity (50 fold). In vitro Lipobay had a higher affinity (110x) for the enzyme than does Lovastatin, Simvastatin and pravastatin which resulted in a lower ED50, in vivo compared to Lovastatin. Three metabolites generated by the CYP3A4 enzyme system were equal to the parent in activity. Lipobay was as effective as Gemfibrozil in type lib hypercholesteremia and had no age or gender effects. It decreased plasma levels of VLDL and LDL cholesterol by a mechanism similar to other HMG-CoA reductase inhibitors. The (-)- antipode is completely inactive indicating a high stereospecificity by the enzyme. It is therapeutically useful at ultra-low doses which may minimize any drug-drug interactions.
Chemical PropertiesSolid
OriginatorBayer (Germany)
UsesA competitive inhibitor of HMG-CoA reductase.
DefinitionChEBI: The sodium salt of cerivastatin. Formerly used to lower cholesterol and prevent cardiovascular disease, it was withdrawn from the market worldwide in 2001 following reports of a severe form of muscle toxicity.
Brand nameBaycol (Bayer).
HazardA poison by ingestion.
Cerivastatin sodium Preparation Products And Raw materials
Tag:Cerivastatin sodium(143201-11-0) Related Product Information
HYDROXY CERIVASTATIN, SODIUM SALT Desmethyl Cerivastatin, Sodium Salt Atorvastatin 3-HEPTENOIC ACID DESMETHYL CERIVASTATIN, SODIUM SALT DESMETHYL HYDROXY CERIVASTATIN, SODIUM SALT CERIVASTATIN, SODIUM SALT Propylthiouracil Fluvastatin sodium salt sodium Sulfasalazine Desmethyl Cerivastatin-O-b-D-glucuronide 3-Pyridinemethanol,2,6-dimethyl-(9CI) 3-(3-PYRIDYL)-2-PROPEN-1-OL 3-METHYL-5-VINYLPYRIDINE Cerivastatin sodium Phenylacetone Hydroxy silicone oil