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Fluvastatin sodium salt

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Company Name: Capot Chemical Co.,Ltd.
Tel: +86-571-85586718
Products Intro: Product Name:Fluvastatin sodium salt
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Products Intro: Product Name:Fluvastatin sodium salt
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: CAS:93957-55-2
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: PI & PI BIOTECH INC.
Tel: 020-81716320
Products Intro: Product Name:Fluvastatin sodium
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Remarks:Sodium (3RS,5SR,6E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoate
Tel: +86 21 5161 9050/ 5187 7795
Products Intro: Product Name:Fluvastatin sodium
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG

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Fluvastatin sodium salt Basic information
Commonly used cholesterol-lowering drugs Chemical Properties Uses production method
Product Name:Fluvastatin sodium salt
Synonyms:InSolution Fluvastatin, Sodium Salt - CAS 93957-55-2 - Calbiochem;(+/-)-(3R',5S',6E)-7-[3-(4-FLUOROPHENYL)-1-ISOPROPYLINDOL-2-YL]-3,5-DIHYDROXY-6-HEPTENOATE, SODIUM;FLUVASTATIN NA;FLUVASTATIN SODIUM;FLUVASTATIN SODIUM SALT;sodium (3r,5s,6e)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1h-indol-2-yl]-3,5-dihydroxy-6-heptenoate;(r*,s*-(e))-monosodiumsal(+-)-2-yl);3,5-dihydro-7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1h-indol-6-heptenoicaci
Product Categories:API;API Reference Standard;Antihyperlipoproteinemic;Intermediates & Fine Chemicals;Pharmaceuticals;HMG-CoA reductase
Mol File:93957-55-2.mol
Fluvastatin sodium salt Structure
Fluvastatin sodium salt Chemical Properties
Melting point 194-197°C
storage temp. Desiccate at -20°C
solubility H2O: ≥9mg/mL
form powder
color white to tan
Merck 14,4218
CAS DataBase Reference93957-55-2(CAS DataBase Reference)
Safety Information
WGK Germany 3
RTECS MJ9675050
HS Code 2933995300
MSDS Information
Fluvastatin sodium salt Usage And Synthesis
Commonly used cholesterol-lowering drugsFluvastatin sodium salt is commonly used as a cholesterol-lowering drug, cholesterol-lowering effect is very good, the trade name of the commercially available products is Lescol,which is produced by Novartis. Fluvastatin sodium salt is a fully synthetic cholesterol-lowering drug, it belongs to methylglutaryl coenzyme A (HMC-CoA) reductase inhibitors, the main function is performed in the liver ,it can transform HMG-CoA into 3-methyl-3,5-dihydroxy acid, it can inhibit the synthesis of endogenous cholesterol ,and reduce cholesterol content in liver cells, it can stimulate the synthesis of low density lipoprotein (LDL) receptors,and enhance the uptake of LDL particles, reduce the plasma total cholesterol can significantly reduce total cholesterol, LDL cholesterol, triglycerides, and increase high-density lipoprotein cholesterol.
The above information is edited by the chemicalbook of Tian Ye.
Chemical PropertiesMelting point 194~197 ℃.
UsesHMG-CoA reductase inhibitors.
production method1. After condensation of (chloroacetyl) fluorobenzeneand N-isopropyl aniline , the compound (I) is obtained. Then in acetonitrile, under the presence of phosphorus oxychloride, react with N, N-dimethylamino acrolein , the compound (Ⅱ) is obtained. Compound (Ⅱ) in the role of a strong base, after condensation with methyl acetoacetate , and then splitting ,the compound (Ⅲ) is produced. At-77 ~-74 ℃, the compound (Ⅲ) is added dropwise into a mixture of boron sodium borohydride , methanol, tetrahydrofuran and diethyl methoxy ,stir 30min; cyclic boronic ester obtained in ethyl acetate is treated with 30% hydrogen peroxide; then it is hydrolyzed to obtain fluvastatin sodium.
2. the compound (Ⅳ)is obtained by catalytic hydrogenation of Phloroglucinol . React it With tert-butyldiphenylsilyl chloride to produce the compound (V), and then oxidize it to generate (Ⅵ). After oxidation of chloroperbenzoic acid to obtain (Ⅶ), (Ⅷ) is produced through ring-opening . And then it is oxidized to (IX) . (Ⅺ) is obtained through condensation of (Ⅸ) and intermediate x , after deprotection and hydrolysis, obtain fluvastatin sodium. Intermediate (X) can be made through starting from the compound (I), via formylation, reduction, chlorination, and then reacting with triphenylphosphine .
DescriptionFluvastatin sodium is the fourth HMG-CoA reductase inhibitor to reach the market as a dietary adjunct for lowing total and low-density lipoprotein (LDL) cholesterol. Fluvastatin sodium is the first totally synthetic inhibitor of its class and has more potent effects on reducing serum total and LDL cholesterol and serum triglyceride levels than compactin or lovastatin. Moreover, fluvastatin exhibits a unique set of pharmacological properties including a biopharmaceutical profile most consistent with hepatoselectivity. It has been reported to be well tolerated and to exhibit a safety profile superior to other agents of its class. The main mechanism by which HMG-CoA reductase inhibitors lower plasma cholesterol has been suggested to be up-regulation of hepatocellular LDL-receptor expression and enhancement of receptor-mediated clearance and catabolism of LDL cholesterol.
Chemical PropertiesYellow Powder
OriginatorSandoz (Switzerland)
UsesA synthetic HMG-CoA reductase inhibitor. Antilipemic
UsesAnti- hyperlipoproteinemic;'HMG CoA reductase inhibitor
Brand nameLescol (Novartis).
Biological ActivityOrally active, potent and competitive HMG-CoA reductase inhibitor (IC 50 = 40 -100 nM at human liver microsomes). Inhibits vascular smooth muscle proliferation in vitro (IC 50 = 70 nM) and exhibits antihypercholesterolemic and antioxidant activity in vivo .
Tag:Fluvastatin sodium salt(93957-55-2) Related Product Information
Sodium bicarbonate Sodium benzoate Sodium carbonate sodium Pravastatin sodium FLUVASTATIN[METHYL-(±)-(E)-7-[3’-(4”-FLUOROPHENYL )-1’-(1”-METHYLETHYL)INDOL-2’-YL]-3,5- DIHYDROXY-6- HEPTENOATE ],FLUVASTATIN,FLUVASTATIN NA,FLUVASTATIN SODIUM,FLUVASTATIN SODIUM 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Sodium chloride Chlorodimethylphenylsilane (2-Methoxyethyl)benzene 2-Butanone ATORVASTATIN SODIUM 1-Hydroxyethylidene-1,1-diphosphonic acid Silicone oil (high temperature) Sodium formate Sodium acetate Diclofenac sodium Sodium gluconate