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| | 2,3,4-Trimethoxybenzoic acid Basic information |
| Product Name: | 2,3,4-Trimethoxybenzoic acid | | Synonyms: | Benzoic acid, 2,3,4-trimethoxy-;2,3,4-TRIMETHOXYBENZOIC ACID;AKOS 214-77;LABOTEST-BB LT00454915;RARECHEM AL BO 0027;2,3,4-TRIMETHOXYBENZOIC ACID, 98+%;2,3,4-Trimethoxybenzoic;2,3,4-TRIMETHOXYBENZOIC ACID 99% | | CAS: | 573-11-5 | | MF: | C10H12O5 | | MW: | 212.2 | | EINECS: | 209-350-0 | | Product Categories: | Carbonyl Compounds;Carboxylic Acids;FINE Chemical & INTERMEDIATES;C10;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Organic acids | | Mol File: | 573-11-5.mol |  |
| | 2,3,4-Trimethoxybenzoic acid Chemical Properties |
| Melting point | 99-102 °C (lit.) | | Boiling point | 312.03°C (rough estimate) | | density | 1.3006 (rough estimate) | | refractive index | 1.5140 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | pka | 4.24±0.10(Predicted) | | form | Crystalline Powder | | color | White to off-white | | BRN | 2696073 | | CAS DataBase Reference | 573-11-5(CAS DataBase Reference) | | NIST Chemistry Reference | 2,3,4-Trimethoxybenzoic acid(573-11-5) |
| Risk Statements | 36/37/38 | | Safety Statements | 24/25 | | WGK Germany | 3 | | HS Code | 29189900 |
| | 2,3,4-Trimethoxybenzoic acid Usage And Synthesis |
| Chemical Properties | WHITE TO OFF-WHITE CRYSTALLINE POWDER | | Uses | 2,3,4-Trimethoxybenzoic acid was used in the synthesis of tropoloisoquinoline alkaloid pareitropone. It was also used in the synthesis of isomeric tris(pyrogallol) derivatives and naphthoic acid. | | Synthesis | General procedure for the synthesis of 2,3,4-trimethoxybenzoic acid from 2,3,4-trimethoxybenzaldehyde: To a stirred solution of 2,3,4-trimethoxybenzaldehyde (24.4 g, 124.4 mmol) in methanol (200 mL) was added an aqueous 50% potassium hydroxide solution (KOH, 22.4 g). The mixture was then heated to reflux. A 30% hydrogen peroxide solution (180 mL) was added dropwise over 30 minutes and the mixture was continued to reflux for 8 hours. After the oxidation reaction was complete, the reaction mixture was cooled and sodium bisulfite (NaHSO3) was added. Methanol was removed by distillation under reduced pressure and the resulting solution was acidified to acidity with concentrated hydrochloric acid. The precipitated 2,3,4-trimethoxybenzoic acid (25.0 g, 95% yield) was collected by filtration. | | References | [1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 9, p. 2671 - 2677
[2] Tetrahedron Letters, 2008, vol. 49, # 6, p. 1083 - 1086
[3] Helvetica Chimica Acta, 1924, vol. 7, p. 362
[4] Synthetic Communications, 2006, vol. 36, # 5, p. 679 - 683 |
| | 2,3,4-Trimethoxybenzoic acid Preparation Products And Raw materials |
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