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Mifepristone

Mifepristone Suppliers list
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd.
Tel: +86-10-60279497 +86(0)15646567669
Email: sales01@cooperate-pharm.com
Products Intro: Product Name:Mifepristone
CAS:84371-65-3
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:Mifepristone
CAS:84371-65-3
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070;product@chemlin.com.cn
Email: product@chemlin.com.cn
Products Intro: CAS:84371-65-3
Purity:98% Package:g-Kg Remarks:Light yellow crystalline powder
Company Name: Nanjing Finetech Chemical Co., Ltd.
Tel: 025-85710122 17714198479
Email: sales@fine-chemtech.com
Products Intro: CAS:84371-65-3
Purity:99%min Package:1KG;10KG;100KG;500KG;100g Remarks:ISO certified
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Email: zheyansh@163.com
Products Intro: Product Name:Mifepristone
CAS:84371-65-3
Purity:98% Package:1g/5g/25g

Lastest Price from Mifepristone manufacturers

  • Mifepristone
  • US $1.00 / Kg/Drum
  • 2019-10-29
  • CAS:84371-65-3
  • Min. Order: 25Kg/Drum
  • Purity: 99%
  • Supply Ability: 1ton
  • Mifepristone
  • US $1.00 / KG
  • 2019-07-06
  • CAS:84371-65-3
  • Min. Order: 1G
  • Purity: 98%
  • Supply Ability: 100KG
  • Mifepristone
  • US $1226.00-100.00 / G
  • 2018-12-29
  • CAS:84371-65-3
  • Min. Order: 10G
  • Purity: 99.7%+
  • Supply Ability: 600kg/month
Mifepristone Basic information
Description
Product Name:Mifepristone
Synonyms:Mifeprestone;11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)-estra-9-dien-3-one;11beta-[4-(n,n-dimethylamino)phenyl]-17alpha-(prop-1-ynyl)-delta4,9-estradiene;17-beta)-(11-bet;17beta)-11-[4-(dimethylamino)-phenyl]-17-hydroxy-17-(1-propynyl)estra-(11bet;17-beta-hydroxy-11-beta-(4-dimethylaminophenyl-1)-17-alpha-(prop-1-ynyl)oest;-17beta-ol-3-one;4,9-dien-3-one
CAS:84371-65-3
MF:C29H35NO2
MW:429.59
EINECS:617-559-7
Product Categories:Steroids;Hormone;Acetylenes;Biochemistry;Functionalized Acetylenes;Hydroxyketosteroids;Steroid and Hormone;API;Hormone Drugs;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Intracellular receptor;Nuclear Receptors
Mol File:84371-65-3.mol
Mifepristone Structure
Mifepristone Chemical Properties
Melting point 195-198°C
alpha D20 +138.5° (c = 0.5 in chloroform)
Boiling point 544.13°C (rough estimate)
density 1.0731 (rough estimate)
refractive index 1.6290 (estimate)
storage temp. 2-8°C
form Yellow solid
pka12.94±0.60(Predicted)
Water Solubility 474.8ug/L(22.5 ºC)
Merck 14,6186
InChIKeyVKHAHZOOUSRJNA-GCNJZUOMSA-N
CAS DataBase Reference84371-65-3(CAS DataBase Reference)
Safety Information
Hazard Codes T
Risk Statements 60-61
Safety Statements 53-22-36/37/39-45
WGK Germany 3
RTECS KG2955000
HS Code 29372900
Hazardous Substances Data84371-65-3(Hazardous Substances Data)
Mifepristone Usage And Synthesis
DescriptionMifepristone is a kind of antagonist of the progestational and glucocorticoid hormone. It is mainly used for the treatment of hypercortisolism in patients with nonpituitary cushing syndrome. During the treatment of Cushing’s syndrome, mifepristone takes effect through interfering with the binding of cortisol to its receptor. It reduces the effects of excess cortisol (e.g., high blood sugar levels) without causing decreased cortisol production. It can also be used to end a pregnancy. Its inhibition on progesterone can induce bleeding during the luteal phase and in early pregnancy.  
DescriptionMifepristone is an orally-active progesterone and glucocorticoid receptor antagonist indicated for use as a post-coital contraceptive. In addition to being an abortifacient, mifepristone is reported to be effective in the treatment of ocular hypertension; its potential therapeutic effect in hormone-dependent tumors is currently under investigation.
Chemical PropertiesPale Yellow Solid
OriginatorRoussel-Uclaf (France)
Usesglutamate uptake inhibitor, AMPA blocker
UsesA progesterone and glucocorticoid antagonist, suppresses VEGF production.
UsesA progesterone receptor antagonist with partial agonist activity. Abortifacient.
IndicationsMifepristone is a progesterone receptor antagonist that has a high affinity for glucocorticoid receptors and little agonist effect.This drug has recently been approved for use in the United States for the treatment of hypercortisolism. At high doses, mifepristone blocks negative feedback of the hypothalamic–pituitary axis, thereby increasing endogenous corticotrophin and cortisol levels. Because mifepristone exerts its effects at the receptor level and not by altering glucocorticoid production, elevated serum cortisol and corticotrophin levels may not accurately reflect the effectiveness of the therapeutic regimen. Mifepristone does not inhibit cortisol binding to the mineralocorticoid receptor, so that the resulting corticotrophin disinhibition may cause potassium depletion. Thus, administration of a mineralocorticoid receptor antagonist such as spironolactone may be indicated with mifepristone. Hypoadrenalism, nausea, and drowsiness have been reported during prolonged administration of mifepristone.
Brand nameMifeprex (Danco);Ru-486;Mifegyne.
World Health Organization (WHO)Mifepristone, an antiprogesterone used in combination with a prostaglandin for the termination of early pregnancy, was introduced in 1990. Use of the combination has been associated with episodes of coronary spasm that are attributed to administration of the prostaglandin and which have resulted in several cases of cardiac infarction and ventricular fibrillation. At least one of these incidents has been fatal.
Biological ActivitySelective antagonist at progesterone (PR) and glucocorticoid (GR) receptors in vitro and in vivo . Is a silent antagonist at PR and has a higher affinity than progesterone. Has higher affinity for GR than dexamethasone.
Referenceshttps://pubchem.ncbi.nlm.nih.gov/compound/mifepristone#section=Top
https://www.drugbank.ca/drugs/DB00834
https://www.drugs.com/cdi/mifepristone-tablets.html
Mifepristone Preparation Products And Raw materials
Raw materialsTetrahydrofuran-->N,N-Dimethylaniline-->Isopropyl ether-->Dimethyl sulfide
Tag:Mifepristone(84371-65-3) Related Product Information
Misoprostol Levonorgestrel Metronidazole mifepristone methochloride N-DESMETHYL MIFEPRISTONE,N-Demethyl Mifepristone Mifepristone(RU486) Didemethyl Mifepristone,DIDESMETHYL MIFEPRISTONE,N-Didesmethyl Mifepristone Mifepristone-d3 22-Hydroxy Mifepristone-d6 Estr-9-en-3-one, 11-[4-(dimethylamino)phenyl]-5,17-dihydroxy-17-(1-propynyl)-, cyclic 1,2-ethanediyl acetal, (5a,11b,17b)- RU486 (Mifepristone) Mifepristone,Methandrostenolone Toripristone MIFEPRISTONE, [N-METHYL-3H] RU-486 (MIFEPRISTONE), [N-METHYL-3H] HYDROXY MIFEPRISTONE,22-Hydroxy Mifepristone Mifepristone CHLOROPHOSPHONAZO III