SBI-115
| 中文名称 | SBI-115 |
|---|---|
| 中文同义词 | 5-氯-2-(乙基磺酰基)嘧啶-4-羧酸间甲苯酚酯;SB-115游离;化合物SBI-115 |
| 英文名称 | m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylate |
| 英文同义词 | SBI115;SBI-115;SBI-115; SBI 115; SBI115;4-Pyrimidinecarboxylic acid, 5-chloro-2-(ethylsulfonyl)-, 3-methylphenyl ester;3-Methylphenyl 5-chloro-2-(ethylsulfonyl)-4-pyrimidinecarboxylate;m-tolyl 5-chloro-2-(ethylsulfonyl)pyrimidine-4-carboxylate;SBI 115;G protein-coupled Bile Acid Receptor 1,GPCR19,TGR5,SBI115,GPBAR1,Inhibitor,SBI-115,SBI 115,G-protein coupled receptor 19,inhibit |
| CAS号 | 882366-16-7 |
| 分子式 | C14H13ClN2O4S |
| 分子量 | 340.78 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 882366-16-7.mol |
| 结构式 |  |
SBI-115 性质
| 沸点 | 529.7±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.386±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO:109.0(最大浓度 mg/mL);319.86(最大浓度 mM) |
| 酸度系数(pKa) | -7.73±0.49(Predicted) |
SBI-115 是一种新型的 TGR5 (GPCR19) 拮抗剂。SBI-115 在囊性胆管细胞中可抑制细胞增殖，降低胆管细胞球状细胞的生长速率和cAMP的水平。
| Target | Value |
|
TGR5
() |
SBI-115 (100-200 µM, 24 hours) inhibits proliferation triggered by pre-treatment of cystic cholangiocytes with Taurolithocholic acid (TLCA) in shRNA-transfected ADPKD cholangiocytes.
Cell Proliferation Assay
| Cell Line: | shRNA-transfected ADPKD cholangiocytes |
| Concentration: | 100, 200 µM |
| Incubation Time: | 24 hours |
| Result: | Inhibited proliferation (by 32-48%) triggered by pre-treatment of cystic cholangiocytes with TLCA. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-111534 | SBI-115 | 1 mg | 272元 | |
| 2024/01/25 | HY-111534 | SBI-115; SBI 115; SBI115 SBI-115 | 882366-16-7 | 5mg | 600元 |