软木肟酸
| 中文名称 | 软木肟酸 |
|---|---|
| 中文同义词 | 辛烷-1,8-二氧肟酸;软木肟酸;次异羟肟酸;N1,N8-二羟基辛烷二酰胺;SUBEROYL BIS-HYDROXAMIC ACID (SBHA),HDAC抑制剂;软木肟酸,10 MM DMSO 溶液 |
| 英文名称 | Suberohydroxamic acid |
| 英文同义词 | ODHA;OCTANE-1,8-DIHYDROXAMIC ACID;SBHA;SUBERIC BISHYDROXAMATE;SUBEROHYDROXAMIC ACID;SUBEROYL BISHYDROXAMIC ACID;STAT3 (PTYR705);[PTYR705]-STAT3 |
| CAS号 | 38937-66-5 |
| 分子式 | C8H16N2O4 |
| 分子量 | 204.22 |
| EINECS号 | |
| 相关类别 | 医药中间体;合成;研究用样品;Amines;Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Hydroxylamines;Nitrogen Compounds;Organic Building Blocks |
| Mol文件 | 38937-66-5.mol |
| 结构式 |  |
软木肟酸 性质
| 熔点 | 153-155 °C(lit.) |
|---|---|
| 密度 | 1.219±0.06 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | 可溶于水中 |
| 酸度系数(pKa) | 9.18±0.20(Predicted) |
| 形态 | 冻干粉 |
| 颜色 | 白色至浅米色 |
| 稳定性 | 吸湿性 |
| InChI | 1S/C8H16N2O4/c11-7(9-13)5-3-1-2-4-6-8(12)10-14/h13-14H,1-6H2,(H,9,11)(H,10,12) |
| InChIKey | IDQPVOFTURLJPT-UHFFFAOYSA-N |
| SMILES | ONC(=O)CCCCCCC(=O)NO |
| Target | Value |
|
HDAC1
(Cell-free assay) | 0.25 μM |
|
HDAC3
(Cell-free assay) | 0.3 μM |
Suberoyl bis-hydroxamic acid (10, 20 or 50 μM; 24 hours) combination with TRAIL improves apoptosis extent, and when TRAIL is combined with 20 μM SBHA (itself causing only 10–15% apoptosis), resulting in 45–50% cell death.Suberoyl bis-hydroxamic acid (20-50 μM; 10-20 hours) alone has little effect on the expression of the proteins Bcl-xL, Mcl-1, and has albeit mildeffect on Bax. When it combines with TRAIL,which increases the ratio of relative protein expression of Bcl-xL and Bax in early periods, while the change in the ratio of Mcl-1 and Bax increases later in MM-BI and Ist-Mes2 cells.Suberoyl bis-hydroxamic acid (30 μM; 6 hours) causes accumulation of acetylated histone H4 in MEL cells.
Apoptosis Analysis
| Cell Line: | MM-BI and Ist-Mes2 cells |
| Concentration: | 10 μM, 20 μM or 50 μM |
| Incubation Time: | 24 hours |
| Result: | Showed a cooperative effect in cell apoptosis. |
Suberoyl bis-hydroxamic acid (intraperitoneal injection; 200 mg/kg; every 2 days; 12 days) reveals a marked increase in the active form of Notch1 (NICD) with a concomitant decrease in ASCL1. It reduces the MTC tumor growth.
| Animal Model: | Nude mice injected with human MTC cells |
| Dosage: | 200 mg/kg |
| Administration: | Intraperitoneal injection; every 2 days; 12 days |
| Result: | Resulted in an average 55% inhibition of tumor growth in SBHA treatment group. |
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| 海关编码 | 2928009090 |
| 存储类别 | 11 - 可燃固体 |
| 提供商 | 语言 |
|---|---|
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-W009776 | 软木肟酸 Suberoyl bis-hydroxamic acid | 38937-66-5 | 50mg | 100元 |
| 2026/06/05 | HY-W009776 | 软木肟酸 Suberoyl bis-hydroxamic acid | 38937-66-5 | 10mM * 1mLin DMSO | 110元 |