- 5-Formylsalicylic acid
-
- $15.00 / 1KG
-
2021-07-02
- CAS:616-76-2
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 5-Formylsalicylic acid
-
- $150.00 / 1KG
-
2020-09-15
- CAS:616-76-2
- Min. Order: 1KG
- Purity: 99.9%
- Supply Ability: 20tons
|
| | 5-Formylsalicylic acid Basic information |
| | 5-Formylsalicylic acid Chemical Properties |
| Melting point | 250 °C (dec.) (lit.) | | Boiling point | 214.32°C (rough estimate) | | density | 1.2208 (rough estimate) | | refractive index | 1.4611 (estimate) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | powder | | pka | 2.67±0.10(Predicted) | | color | brownish-yellow | | BRN | 2640881 | | Stability: | Hygroscopic | | InChI | InChI=1S/C8H6O4/c9-4-5-1-2-7(10)6(3-5)8(11)12/h1-4,10H,(H,11,12) | | InChIKey | UTCFOFWMEPQCSR-UHFFFAOYSA-N | | SMILES | C(O)(=O)C1=CC(C=O)=CC=C1O | | CAS DataBase Reference | 616-76-2(CAS DataBase Reference) |
| Risk Statements | 36/37/38 | | Safety Statements | 22-24/25 | | WGK Germany | 3 | | HS Code | 29189900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1 |
| | 5-Formylsalicylic acid Usage And Synthesis |
| Chemical Properties | light beige fine crystalline powder | | Uses | 5-Formylsalicylic Acid is used as a selective phase for the extraction of iron(III) in silica gel. It is also used in preparation of styrylquinolines as potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells. | | Definition | ChEBI: 5-formylsalicylic acid is a monohydroxybenzoic acid in which a benzoic acid nucleus is substituted at positions 2 and 5 by a formyl group and an hydroxy group respectively. It is a member of benzaldehydes, a monohydroxybenzoic acid and a member of phenols. It is functionally related to a salicylic acid. | | Synthesis | General procedure for the synthesis of 5-formyl-2-hydroxybenzoic acid from 5-methylsalicylic acid: a mixture of the substrate 5-methylsalicylic acid (1 mmol), cobalt salt (n1 mol%), and NaOH (n2 eq.) in ethylene glycol (5 mL) was reacted with oxygen (1 atm) with stirring for 8 hours at 80 °C. Upon completion of the reaction, hydrochloric acid (10 mL, 2%) and methyl tert-butyl ether (MTBE, 10 mL) were added sequentially to the reaction mixture. The organic layer was separated and the aqueous phase was further extracted with MTBE (10 mL x 2). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated to give the residue. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, 10/1) to afford the target product 5-formyl-2-hydroxybenzoic acid. | | References | [1] Tetrahedron Letters, 2014, vol. 55, # 8, p. 1406 - 1411
[2] Molecular Catalysis, 2018, vol. 453, p. 121 - 131 |
| | 5-Formylsalicylic acid Preparation Products And Raw materials |
|