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| | 9-Fluorenylmethyl chloroformate Basic information |
| | 9-Fluorenylmethyl chloroformate Chemical Properties |
| Melting point | 62-64 °C(lit.) | | Boiling point | 365.79°C (rough estimate) | | density | 1.1780 (rough estimate) | | refractive index | 1.5330 (estimate) | | storage temp. | 2-8°C | | solubility | dioxane: 0.1 g/mL, clear, colorless | | form | Crystalline Powder | | color | White to very pale yellow | | Sensitive | Moisture Sensitive | | BRN | 2279177 | | Stability: | Hygroscopic, Moisture Sensitive | | InChI | InChI=1S/C15H11ClO2/c16-15(17)18-9-14-12-7-3-1-5-10(12)11-6-2-4-8-13(11)14/h1-8,14H,9H2 | | InChIKey | IRXSLJNXXZKURP-UHFFFAOYSA-N | | SMILES | C(Cl)(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O | | LogP | 3.45 | | CAS DataBase Reference | 28920-43-6(CAS DataBase Reference) |
| Hazard Codes | C,T | | Risk Statements | 34-20/21/22 | | Safety Statements | 26-36/37/39-45-27 | | RIDADR | UN 3261 8/PG 2 | | WGK Germany | 3 | | RTECS | LQ6250000 | | F | 10-21 | | TSCA | No | | HazardClass | 6.1 | | PackingGroup | II | | HS Code | 29159020 |
| | 9-Fluorenylmethyl chloroformate Usage And Synthesis |
| Chemical Properties | White to off white crystalline powder | | Uses | 9-Fluorenylmethyl chloroformate is an N-Protecting agent for peptides research and was used for the pre-column derivatization of the biogenic amines (BAs) cadaverine (Cad), histamine (Him), octopami ne (Ocp), phenylethylamine (Pea), putrescine (Put), spermidine (Spd), spermine (Spm), tyramine (Tym). | | Uses | 9-Fluorenylmethyl chloroformate can act as reagent for the introduction of Fmoc-amino-protecting group, which is stable towards acids but is readily cleaved under mildly basic non-hydrolytic conditions. | | Uses | 9-Fluorenylmethyl chloroformate can be used as N-protecting reagent for oligonucleotide and peptide syntheses. | | General Description | Fmoc chloride is a derivatizing agent. | | Flammability and Explosibility | Not classified | | Safety Profile | A poison. Mutation
data reported. A corrosive. When heated to
decomposition it emits toxic vapors of Cl-. | | Purification Methods | If the IR contains no OH bands (at ~3000 cm-1) due to the hydrolysis product 9-fluorenylmethanol, then purify it by recrystallisation from dry Et2O. IR (CHCl3) has a band at 1770 cm-1 (C=O), and the NMR (CDCl3) has at 4-4.6 (m 2H, CHCH2) and 7.1-7.8 (m, 8 aromatic H) ppm. The azide (FMOC-N3) has m 89-90o (from -1hexane) and IR (CHCl3) at 2135 (N3) and 1730 (C=O) cm , and the carbazate (FMOC-NHNH2) has m 171o(dec) (from nitromethane), IR (KBr) 3310, 3202 (NH) and 1686 (CONH) cm-1. [Caprino & Han J Org Chem 37, 3404 1972 , J Am Chem Soc 92 5748 1970, Koole et al. J Org Chem 59 1657 1989, Fürst et al. J Chromatogr 499 537 1990.] |
| | 9-Fluorenylmethyl chloroformate Preparation Products And Raw materials |
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