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CAY10505

CAY10505 更多供应商
公司名称: 济南精合医药科技有限公司  
联系电话: +86 (531) 88811783
产品介绍: 英文名称:CAY10505
CAS:1218777-13-9
纯度:99% 包装信息:5Mg, 10Mg, 20Mg, 50Mg
公司名称: BOC Sciences  
联系电话: 16314854226
产品介绍: 英文名称:CAY10505
CAS:1218777-13-9
公司名称: 大连美仑生物技术有限公司  
联系电话: 0411-62910999 13889544652
产品介绍: 英文名称:CAY-10505
CAS:1218777-13-9
纯度:>98%,PI3Kγ抑制剂 包装信息:10MG;50MG; 备注:MB3572
公司名称: Wuhan NCE Biomedical Co.,Ltd.  
联系电话: 4000-027-021 |24 hour enquiry :+86-13986109188 |English:+86-15623472865 |Japanese:+81-08033611988
产品介绍: 英文名称:CAY10505
CAS:1218777-13-9
纯度:99% HPLC 包装信息:50Mg,100Mg,500Mg,1g,5g,10g,50g,100g,500g,1kg 备注:XYA0144
公司名称: 上海皓元医药股份有限公司  
联系电话: 86-21-58998985
产品介绍: 英文名称:CAY10505
CAS:1218777-13-9
纯度:>98% 包装信息:420RMB/10mg 备注:试剂级
最新发布供应信息
PI3Kγ抑制剂(CAY10505)
价格:询价
上海泽叶生物科技有限公司
2022/08/09 13:37:17
CAY10505
价格:¥400mg
南京百鑫德诺生物科技有限公司
2020/03/30 13:12:37
CAY10505
生物活性靶点体外研究体内研究 MSDS 用途与合成方法 CAY10505价格(试剂级) 上下游产品信息
中文名称:CAY10505
中文同义词:(5E)-5-[[5-(4-氟苯基)-2-呋喃基]亚甲基]-2,4-噻唑烷二酮;PI3KΓ抑制剂(CAY10505)
英文名称:CAY10505
英文同义词:CAY10505;(5E)-5-[[5-(4-Fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione;(E)-5-((5-(4-fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione;CAY10505 ( 5E)-5-[[5-(4-Fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione;CAY10505, >=98%;2,4-Thiazolidinedione, 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-, (5E)-;CAY10505 USP/EP/BP
CAS号:1218777-13-9
分子式:C14H8FNO3S
分子量:289.28
EINECS号:
相关类别:小分子抑制剂,天然产物;细胞生物学试剂;Akt;mTOR;PI3K;PI3K/Akt/mTOR;Inhibitors
Mol文件:1218777-13-9.mol
CAY10505
CAY10505 性质
密度 1.466
酸度系数(pKa)7.21±0.20(Predicted)
CAY10505 用途与合成方法
生物活性CAY10505 是一种有效的选择性 PI3Kγ 抑制剂,作用于神经元细胞,IC50 为 30 nM。
靶点

PI3Kγ

30 nM (IC 50 , Neurons)

体外研究

A class IB PI3Kγ isoform inhibitor CAY10505 at 200 nM (IC 50 =30 nM) partially reduces the baicalein-induced Akt phosphorylation in neurons. The pharmacological PI3K inhibitor CAY10505 (PIK3CG) is tested on an extended panel of multiple myeloma (MM) cell lines and freshly isolated primary MM samples. MM cells are CAY10505-treated for 3 d (MM cell lines) or 5 d (primary MM cells) respectively, and survival is analysed by flow cytometry (annexin V-FITC/PI staining). Treatment of bone marrow stromal cells (BMSCs)-co-cultured primary MM samples with the PIK3CA inhibitor CAY10505 results in anti-survival effects (mean survival relative to DMSO-treated controls: CAY10505: 84±14%, tested at 10 μM).

体内研究

Administration of CAY10505 (0.6 mg/kg, p.o.), Losartan (25 mg/kg, p.o.), or Atorvastatin (30 mg/kg, p.o.) significantly increases serum nitrite and (or) nitrate concentrations in hypertensive rats. Acetylcholine (ACh) and Sodium nitroprusside (SNP) produce endothelium-dependent and-independent relaxation in isolated rat aortic ring precontracted with Phenylephrine (3 μM), in a dose dependent manner. Administration of CAY10505 (0.6 mg/kg,p.o.), Losartan (25 mg/kg, p.o.), or Atorvastatin (30 mg/kg, p.o.) significantly prevents hypertension-induced attenuation of ACh-induced endothelium-dependent relaxation. Deoxycorticosterone acetate salt (DOCA, 40 mg/kg, s.c.) induced hypertension markedly attenuates acetylcholine-induced endothelium-dependent relaxation, but does not affect SNP-induced endotheliumindependent relaxation.

安全信息
CAY10505 价格(试剂级)
更新日期产品编号产品名称CAS编号包装价格
2022/07/01HY-13530CAY105051218777-13-910mg420元
2022/07/01HY-13530CAY105051218777-13-910mM * 1mLin DMSO500元
"CAY10505" 相关产品信息()
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