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1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE

1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: 571-85586718 +8613336195806
Email: sales@capotchem.com
Products Intro: Product Name:1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
CAS:321-64-2
Purity:NLT 98% Package:1G;1KG;100KG
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070
Email: product@chemlin.com.cn
Products Intro: CAS:321-64-2
Purity:95% Package:g-Kg Remarks:Beige solid
Company Name: Zhejiang ZETian Fine Chemicals Co. LTD
Tel: 18957127338
Email: stella@zetchem.com
Products Intro: Product Name:1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
CAS:321-64-2
Purity:0.99 Package:5KG;1KG Remarks:Have any requirements, pls contact sales@zetchem.com
Company Name: career henan chemical co
Tel: +86-0371-86658258 15093356674;
Email: factory@coreychem.com
Products Intro: Product Name:tacrine
CAS:321-64-2
Purity:98% HPLC Package:1KG;1USD
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Tacrine;CS 12602;Tetrahydroaminocrine;Tacrinum
CAS:321-64-2
Package:1 g Remarks:REAGENT;FOR LABORATORY USE ONLY

1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE manufacturers

  • tacrine
  • tacrine pictures
  • $1.00 / 1KG
  • 2020-02-17
  • CAS:321-64-2
  • Min. Order: 1KG
  • Purity: 98% HPLC
  • Supply Ability: 10 tons
1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Basic information
Product Name:1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
Synonyms:1,2,3,4-tetrahydro-9-acridinamin;1,2,3,4-tetrahydro-9-amino-acridin;1,2,3,4-Tetrahydro-9-aminoacridine;5-Amino-6,7,8,9-tetrahydroacridine;Acridine, 1,2,3,4-tetrahydro-9-amino-;Acridine, 9-amino-1,2,3,4-tetrahydro-;Acridine, 9-aminotetrahydro-;CS 12602
CAS:321-64-2
MF:C13H14N2
MW:198.26
EINECS:206-291-2
Product Categories:
Mol File:321-64-2.mol
1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Structure
1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Chemical Properties
Melting point 183.5℃
Boiling point 325.59°C (rough estimate)
density 0.9827 (rough estimate)
refractive index 1.4400 (estimate)
storage temp. 4°C, away from moisture and light
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka9?+-.0.20(Predicted)
color White to Pale Yellow
CAS DataBase Reference321-64-2(CAS DataBase Reference)
Safety Information
MSDS Information
1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Usage And Synthesis
DescriptionIn the 1950s, tacrine was used experimentally to reverse cholinergic coma in animals. In the 1960s, tacrine was used to reverse the effects of phencyclidine-like drugs. It was also marketed for many years as a respiratory stimulant. In 1993, the US Food and Drug Administration approved tacrine for the treatment of symptoms of mild to moderate Alzheimer’s disease.
UsesThe current use of tacrine is limited due to its poor oral bioavailability, the necessity for four daily doses, and serious side effects (including nausea, vomiting, dry mouth, indigestion, diarrhea, loss of appetite, urinary incontinence, collapse, convulsions, and hepatotoxicity). Currently, newer cholinesterase inhibitors (such as donepezil, rivastigmine, and galantamine) are preferred over tacrine.
DefinitionChEBI: Tacrine is a member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is a member of acridines and an aromatic amine. It is a conjugate base of a tacrine(1+).
Synthesis Reference(s)Tetrahedron Letters, 4, p. 1277, 1963 DOI: 10.1039/jr9630005127
Toxicity evaluationTacrine has numerous mechanisms of action. The putative principal mechanism of action of tacrine for Alzheimer’s disease is reversible inhibition of acetylcholinesterase (AChE), which thereby slows the breakdown of the chemical messenger acetylcholine (ACh) in the brain. Tacrine also inhibits butyrylcholinesterase activity. In addition, tacrine blocks sodium and potassium channels. Tacrine also acts as a histamine N-methyltransferase inhibitor.
At a therapeutic dose, tacrine causes liver toxicity. Cytotoxicity studies using the human liver cell line HepG2 showed that a therapeutic blood concentration of tacrine induces reactive oxygen species production and glutathione depletion, suggesting that oxidative stress might be involved in tacrine hepatotoxicity.
Tag:1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE(321-64-2) Related Product Information
9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE HYDRATE,99+% 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE, MONOHYDROCHLORIDE,1,2,3,4-Tetrahydro-9-Acridinamine Hydrochloride Dihydrate Velnacrine N-Butyl-1,2,3,4-tetrahydro-9-acridinamine 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE Acridine 9-AMINOACRIDINE 5-Chloro-1,2,3,4-tetrahydro-9-morpholinoacridine hydrochloride 9-AMINO-3,3-DIMETHYL-3,4-DIHYDRO-1(2H)-ACRIDINONE Centbucridine 9-AMINO-1,2,3,4-TETRAHYDRO-ACRIDIN-1-OL, MALEATE 9-(BENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDIN-1-OL, MALEATE TA-03 9-AMINO-7-METHYL-1,2,3,4-TETRAHYDROACRIDINE 9-AMINO-6-CHLORO-1,2,3,4-TETRAHYDRO-ACRIDINE 9-AMINO-7-CHLORO-1,2,3,4-TETRAHYDRO-ACRIDINE 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HCL HYDRATE Suronacrine