ChemicalBook > Product Catalog >API >Antiallergic drugs >Antihistamines >Ebastine

Ebastine

Ebastine Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-571-85586718
Email: sales@capotchem.com
Products Intro: Product Name:Ebastine
CAS:90729-43-4
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Ebastine
CAS:90729-43-4
Purity:99% Package:100g,500g,1kg,5kg,10kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:90729-43-4
CAS:90729-43-4
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: PI & PI BIOTECH INC.
Tel: 18371201331
Email: Sales@pipitech.com
Products Intro: Product Name:Ebastine
CAS:90729-43-4
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:1-[4-(1,1-Dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)piperidin-1-yl]butan-1-one
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070;product@chemlin.com.cn
Email: product@chemlin.com.cn
Products Intro: CAS:90729-43-4
Purity:98% Package:g-Kg Remarks:White crystal powder

Lastest Price from Ebastine manufacturers

  • Ebastine
  • US $1.00-1.00 / KG
  • 2020-05-12
  • CAS:90729-43-4
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 50tons
  • Ebastine
  • US $1.00 / kg
  • 2019-07-06
  • CAS:90729-43-4
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: Customized
Ebastine Basic information
Description References
Product Name:Ebastine
Synonyms:4'-(1,1-Dimethylethyl)-γ-[4-(diphenylmethoxy)piperidin-1-yl]butyrophenone;4'-tert-Butyl-γ-[4-(diphenylmethoxy)piperidino]butyrophenone;Ebastel-OD;LAS-90;IMp. A (EP): DiphenylMethanol (Benzhydrol);Ebastine Impurity;1-butanone,1-(4-(1,1-dimethylethyl)phenyl)-4-(4-(diphenylmethoxy)-1-piperidiny;4’-tert-butyl-4-(4-(diphenylmethoxy)piperidino)butyrophenone
CAS:90729-43-4
MF:C32H39NO2
MW:469.66
EINECS:635-609-6
Product Categories:Inhibitors;Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:90729-43-4.mol
Ebastine Structure
Ebastine Chemical Properties
Melting point 80-82°C
Boiling point 596.3±50.0 °C(Predicted)
density 1.09±0.1 g/cm3(Predicted)
storage temp. Room temp
solubility Slightly soluble in chloroform, methanol.
form solid
pka8.19±0.10(Predicted)
color white
Merck 14,3484
CAS DataBase Reference90729-43-4(CAS DataBase Reference)
Safety Information
WGK Germany 3
RTECS EL8140000
MSDS Information
Ebastine Usage And Synthesis
DescriptionEbastine belongs to an effective second generation histamine H1 receptor antagonist. One important property of it is that it doesn’t penetrate the blood brain barrier. Therefore, it is capable of blocking the H1 receptor in peripheral tissue without having some specific side effects such as sedation and drowsiness. Ebastine is mainly applied for the treatment of allergic rhinitis, pruritus as well as acting as an alternative drug in Decongestant. Upon entering into the human body, it can subject to the action of hepatic cytochrome P450 3A4 to be converted to an active carboxylic acid metabolite, carebastine. The later one is the major active form in vivo. Under certain range, it can inhibit T cell proliferation and the production of Th2-type pro-inflammatory cytokines through macrophages. Ebastine generally has a high safety property without causing cognitive/psychomotor impairment and sedation, like placebo. However, it can cause side effects such as inflammation of the air-cavities around nose, sore throat, indigestion, nausea, headache, and abdominal pain.
Referenceshttps://pubchem.ncbi.nlm.nih.gov/compound/3191#section=Top
http://www.tabletwise.com/medicine/ebastine/side-effects
http://www.druginfosys.com/drug.aspx?drugcode=897&type=1
DescriptionEbastine is a new once-daily histamine Hl-receptor antagonist with no sedative effects or autonomic impairment at therapeutic doses. It is reported to be effective in the treatment of hay fever, perennial rhinitis, and uticaria. Ebastine's antihistamine activity is attributed to its carboxylic acid metabolite carebastine.
Chemical PropertiesWhite to Off-White Powder
OriginatorAlmirall (Spain)
UsesA nonsedating type histamine H1-receptor antagonist. Antihistaminic
Manufacturing Process(a) A mixture of 4-hydroxypiperidine (40.4 g; 0.4 moles), p-tert-butyl-ω- chlorobutyrophenone (105 g, 0.44 moles), sodium bicarbonate (67.2 g; 0.8 moles) and a crystal of potassium iodide in methyl isobutyl ketone (1 liter) was boiled under reflux for 24 hours. After cooling, the reaction mixture waswashed with water, dried (Na2SO4) and the solvent removed in vacuum. The residue was salified with the stoichiometric amount of fumaric acid in a mixture of acetone and ethanol to give 1-[3-(4-tert-butylbenzoyl)propyl]-4- hydroxypiperidine fumarate (148 g), melting point 163-165°C. This compound was converted into the free base, and 1-[3-(4-tert-butylbenzoyl)propyl]-4- hydroxypiperidine was obtained and recrystallized from a mixture of diethyl ether and petroleum ether (boiling point 50-70°C). 102 g were obtained (yield 84%), melting point 63-65°C.
(b) A mixture of 1-[3-(tert-butylbenzoyl)propyl]-4-hydroxypiperidine (60.68 g; 0.2 moles) and sodium carbonate (42.4 g; 0.4 moles) in methyl isobutyl ketone (500 ml) was heated to the boiling point and a solution of diphenylmethyl bromide (49.42 g; 0.2 moles) in methyl isobutyl ketone (75 ml) was slowly added in 1.5 hours. The resulting mixture was boiled under reflux for another 12 hours, and then another solution of diphenylmethyl bromide (24.71 g; 0.1 moles) in methyl isobutyl ketone (50 ml) was added and the mixture boiled under reflux again for 12 hours. Another solution of diphenylmethyl bromide in the same quantity was added and after refluxing for 12 additional hours the reaction mixture was cooled, washed with water, dried (Na2SO4) and the solvent removed in vacuum.
The residual oil was treated with the stoichiometric amount of fumaric acid in ethanol and 4-diphenylmethoxy-1-[3-(4-tert-butylbenzoyl)propyl]piperidine fumarate crystallized. After recrystallisation from ethanol the pure compound was obtained (88 g; yield 75%), melting point 197-198°C.
Brand nameKestine (Rhone-Poulenc Rorer);Ebastel.
Therapeutic FunctionAntihistaminic, Antiallergic, Calcium entry blocker
Ebastine Preparation Products And Raw materials
Raw materials4-Hydroxypiperidine-->Bromodiphenylmethane-->Sodium bicarbonate-->Potassium iodide
Tag:Ebastine(90729-43-4) Related Product Information
Cetirizine Loratadine Desalkyl Ebastine-d5 EBASTINE IMPURITY D Ebastine Base / Fumerate 1-[3-(4-TERT-BUTYLBENZOYL)-PROPYL]-4-HYDROXYPIPERIDINE/INTERMEDIATE OF EBASTINE EBASTINE FUMERATE Ebastine-D5 Carebastine EBASTINE FUMARATE Methyl 2-(4-(4-chlorobutanoyl)phenyl)-2-methylpropanoate Ebastine Chlorodiphenylphosphine Dichlorodiphenylsilane 1,3-Diphenyl-2-thiourea DI-TERT-BUTYL ETHER 1,5-Diphenylcarbazide (+-) 1-BROMO-2-METHYLBUTANE 95