阿莫地喹
| 中文名称 | 阿莫地喹 |
|---|---|
| 中文同义词 | 氨酚喹;阿莫地喹;氨酚喹啉;阿莫地喹 -D10;阿莫地喹杂质;4-((7-氯喹啉-4-基)氨基)-2-((二乙基氨基)甲基)苯酚;阿莫地喹,10 MM DMSO 溶液;4-((7-氯喹啉-4-基)氨基)-2-((二乙氨基)甲基)苯酚 |
| 英文名称 | Amodiaquine |
| 英文同义词 | 4-((7-chloro-4-quinolyl)amino)-alpha-(diethylamino)-o-creso;4-((7-Chloro-4-quinolyl)amino)-alpha-(diethylamino)-o-cresol;4-[(7-Chloro-4-quinolinyl)amino]-alpha-(diethylamino)-o-cresol;7-Chloro-4-(3-diethylaminomethyl-4-hydroxyphenylamino)quinoline;Amodiaquine, ring-closed;CAM-AQ1;CAM-AQI;Camochin |
| CAS号 | 86-42-0 |
| 分子式 | C20H22ClN3O |
| 分子量 | 355.86 |
| EINECS号 | 201-669-3 |
| 相关类别 | 医药原料药;化合物;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 86-42-0.mol |
| 结构式 |  |
阿莫地喹 性质
| 熔点 | 208°C |
|---|---|
| 沸点 | 478.0±45.0 °C(Predicted) |
| 密度 | 1.258 |
| 储存条件 | -20°C Freezer |
| 溶解度 | DMSO（轻微，超声处理），甲醇（轻微） |
| 形态 | 固体 |
| 酸度系数(pKa) | 9.43±0.50(Predicted) |
| 颜色 | 淡黄色至浅黄色 |
| InChI | InChI=1S/C20H22ClN3O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19/h5-12,25H,3-4,13H2,1-2H3,(H,22,23) |
| InChIKey | OVCDSSHSILBFBN-UHFFFAOYSA-N |
| SMILES | C1(O)=CC=C(NC2C3C(N=CC=2)=CC(Cl)=CC=3)C=C1CN(CC)CC |
| CAS 数据库 | 86-42-0(CAS DataBase Reference) |
| NIST化学物质信息 | Amodiaquine(86-42-0) |
EC50: ~20 μM (Nurr1-LBD (ligand binding domain))
Histamine N-methyltransferase
Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.
Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH
+
neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells.
RT-PCR
| Cell Line: | Primary microglia |
| Concentration: | 10 µM, 15 µM, 20 µM |
| Incubation Time: | 4 hours |
| Result: | Suppressed LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner. |
Amodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice.
| Animal Model: | Male ICR mice (8-10 weeks of age) induced ntracerebral hemorrhage (ICH) |
| Dosage: | 40 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 3 days |
| Result: | Diminished perihematomal activation of microglia/macrophages and astrocytes. |
安全信息
| 毒害物质数据 | 86-42-0(Hazardous Substances Data) |
|---|---|
| 毒性 | LD50 oral in mouse: 550mg/kg |