阿莫地喹
中文名称 | 阿莫地喹 |
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中文同义词 | 氨酚喹;阿莫地喹;氨酚喹啉;阿莫地喹 -D10;阿莫地喹杂质;4-((7-氯喹啉-4-基)氨基)-2-((二乙基氨基)甲基)苯酚 |
英文名称 | Amodiaquine |
英文同义词 | 4-((7-chloro-4-quinolyl)amino)-alpha-(diethylamino)-o-creso;4-((7-Chloro-4-quinolyl)amino)-alpha-(diethylamino)-o-cresol;4-[(7-Chloro-4-quinolinyl)amino]-alpha-(diethylamino)-o-cresol;7-Chloro-4-(3-diethylaminomethyl-4-hydroxyphenylamino)quinoline;Amodiaquine, ring-closed;CAM-AQ1;CAM-AQI;Camochin |
CAS号 | 86-42-0 |
分子式 | C20H22ClN3O |
分子量 | 355.86 |
EINECS号 | 201-669-3 |
相关类别 | 医药原料药;化合物;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
Mol文件 | 86-42-0.mol |
结构式 |
阿莫地喹 性质
熔点 | 208°C |
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沸点 | 478.0±45.0 °C(Predicted) |
密度 | 1.258 |
储存条件 | -20°C Freezer |
溶解度 | DMSO(轻微,超声处理),甲醇(轻微) |
形态 | 固体 |
酸度系数(pKa) | 9.43±0.50(Predicted) |
颜色 | 淡黄色至浅黄色 |
CAS 数据库 | 86-42-0(CAS DataBase Reference) |
NIST化学物质信息 | Amodiaquine(86-42-0) |
EC50: ~20 μM (Nurr1-LBD (ligand binding domain))
Histamine N-methyltransferase
Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.
Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH
+
neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells.
RT-PCR
Cell Line: | Primary microglia |
Concentration: | 10 µM, 15 µM, 20 µM |
Incubation Time: | 4 hours |
Result: | Suppressed LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner. |
Amodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice.
Animal Model: | Male ICR mice (8-10 weeks of age) induced ntracerebral hemorrhage (ICH) |
Dosage: | 40 mg/kg |
Administration: | Intraperitoneal injection; daily; for 3 days |
Result: | Diminished perihematomal activation of microglia/macrophages and astrocytes. |
安全信息
毒害物质数据 | 86-42-0(Hazardous Substances Data) |
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毒性 | LD50 oral in mouse: 550mg/kg |