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2-Bromo-2-nitro-1,3-propanediol

2-Bromo-2-nitro-1,3-propanediol Suppliers list
Company Name: Hebei Dongdu Import and Export Co. LTD
Tel: 15831048222
Email: manager@cndongdu.com
Products Intro: Product Name:Bronopol (BNPD)
CAS:52-51-7
Purity:99% Package:25KG;6USD
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:2-Bromo-2-nitro-1,3-propanediol
CAS:52-51-7
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:2-Bromo-2-nitro-1,3-propanediol
CAS:52-51-7
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
Email: fandachem@gmail.com
Products Intro: Product Name:2-Bromo-2-nitro-1,3-propanediol fandachem
CAS:52-51-7
Purity:As coa Package:As request Remarks:52-51-7
Company Name: Hubei XinRunde Chemical Co., Ltd.
Tel: +8615102730682; +8618874586545
Email: bruce@xrdchem.cn
Products Intro: Product Name:Bronopol
CAS:52-51-7
Purity:99% Package:100g/ bag, 2 kg/ bag, 25kg/ carton or as required Remarks:White crystalline powder

Lastest Price from 2-Bromo-2-nitro-1,3-propanediol manufacturers

  • Bronopol (BNPD)
  • US $6.00 / KG
  • 2020-12-04
  • CAS:52-51-7
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 30 tons
  • Bronopol (BNPD)
  • US $6.00 / KG
  • 2020-09-04
  • CAS:52-51-7
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 80tons/month
2-Bromo-2-nitro-1,3-propanediol Basic information
Product Name:2-Bromo-2-nitro-1,3-propanediol
Synonyms:Bronopol 1g [52-51-7];Broken Ball;2-BroMo-2-nitropropane-1;3-diol (Bronopol);Bronopol(2-BroMo-2-nitro-1,3-propanedio1);2-BroMo-2-nitro-1,3-propanediol, 98% 25GR;Bronopol BNPD;Bronopol 0
CAS:52-51-7
MF:C3H6BrNO4
MW:199.99
EINECS:200-143-0
Product Categories:Antibacterial agent;Antiseptic-water treatment-bactericide-Bronopol;Building Blocks;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Propanes/propenes;FUNGICIDE;Biocide;water treatment agent;Polyols;Food additive;CHEMICAL
Mol File:52-51-7.mol
2-Bromo-2-nitro-1,3-propanediol Structure
2-Bromo-2-nitro-1,3-propanediol Chemical Properties
Melting point 130-133 °C(lit.)
Boiling point 358.0±42.0 °C(Predicted)
density 2.0002 (rough estimate)
refractive index 1.6200 (estimate)
Fp 167°C
solubility H2O: soluble100mg/mL, clear, colorless to faintly yellow
pka12.02±0.10(Predicted)
form Crystals or Crystalline Powder
color White to yellow
Water Solubility 25 g/100 mL (22 ºC)
Merck 14,1447
BRN 1705868
Stability:Stable. Hygroscopic. Incompatible with strong oxidizing agents, strong bases, strong reducing agents, acid chlorides and anhydrides, moisture.
CAS DataBase Reference52-51-7(CAS DataBase Reference)
NIST Chemistry ReferenceBronopol(52-51-7)
EPA Substance Registry SystemBronopol (52-51-7)
Safety Information
Hazard Codes Xn,N
Risk Statements 21/22-37/38-41-50
Safety Statements 26-37/39-61-36/37/39
RIDADR UN 3241 4.1/PG 3
WGK Germany 2
RTECS TY3385000
4.2-8-9-21
TSCA Yes
HazardClass 4.1
PackingGroup III
HS Code 29055999
Hazardous Substances Data52-51-7(Hazardous Substances Data)
ToxicityLD50 in mice, rats (mg/kg): 350, 400 orally (Croshaw)
MSDS Information
ProviderLanguage
Bronopol English
ACROS English
SigmaAldrich English
ALFA English
2-Bromo-2-nitro-1,3-propanediol Usage And Synthesis
DescriptionBronopol, a formaldehyde releaser, was reported as an allergen in dairy workers. In a recent case report, bronopol was contained in a lubricant jelly used for ultrasound examination and caused contact dermatitis in a veterinary surgeon.
Chemical Propertiesoff-white crystalline powder
Chemical PropertiesBronopol is a white or almost white crystalline powder; odorless or with a faint characteristic odor.
OriginatorBronosol,Green Cross,Japan,1977
Usesbactericide; in seed treatment for control of Xanthomonas malvacearum; as a foliar spray for control of a wide range of plantpathogenic bacteria (especially Erwinia amylovora); in antiseptics and as a preservative in cosmetics, cooling fluids, hand and face creams, shampoos, hair dressings, mascaras, cleansing lotions, milk sampling, paints, textiles, humidifiers, pharmaceutical products, washing detergents.
UsesPreservative in cosmetics and toiletries. Antiseptic.
Production MethodsBronopol is synthesized by the reaction of nitromethane with paraformaldehyde in an alkaline environment, followed by bromination. After crystallization, bronopol powder may be milled to produce a powder of the required fineness.
Manufacturing ProcessA mixture of 441 g (3 mols) of calcium chloride dihydrate, 61 g (1 mol) of nitromethane, 163 g (2 mols) of formalin (37% formaldehyde solution) and 470 ml of water was cooled to 0°C and mixed with 5 g of calcium hydroxide while stirring. The temperature thereby rose to 30°C. As soon as the temperature had fallen again, a further 32 g of calcium hydroxide (total of 0.5 mol) were added. The mixture was then cooled to 0°C and with intensive cooling and stirring, 159.8 g (1 mol, 51 ml) of bromine were dropped in at a rate so that the temperature remained at around 0°C. After the addition was ended, the mixture was stirred for a further 2 hours, when the reaction product separated in crystalline form. The product was quickly filtered on a suction filter and the crystalline sludge obtained was taken up in 450 ml of ethylene chloride and dissolved at reflux. Then by addition of magnesium sulfate, undissolved inorganic salts were separated and the solution was slowly cooled whereby 140 g (70% yield) of 2-bromo-2-nitropropane-1,3-diol precipitated in colorless crystals melting at 123°-124°C.
Therapeutic FunctionAntiseptic
General DescriptionWhite crystals. Ignite easily and burn readily. May detonate under strong shock. Decomposes when heated, evolving toxic gases. Toxic by skin absorption, inhalation or ingestion.
Air & Water ReactionsHighly flammable. Water soluble.
Reactivity ProfileIncompatible with strong oxidizing agents, strong bases, strong reducing agents, acid chlorides and acid anhydrides. 2-Bromo-2-nitro-1,3-propanediol is also incompatible with sulfhydryl compounds or with aluminum or iron containers (it is stable in contact with tin or stainless steel).
HazardToxic by all routes of exposure; skin irritant.
Health HazardFire may produce irritating and/or toxic gases. Contact may cause burns to skin and eyes. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution.
Fire HazardFlammable/combustible material. May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form at a temperature that may be above its flash point. May re-ignite after fire is extinguished.
Pharmaceutical ApplicationsBronopol 0.01–0.1% w/v is used as an antimicrobial preservative either alone or in combination with other preservatives in topical pharmaceutical formulations, cosmetics, and toiletries; the usual concentration is 0.02% w/v.
Contact allergensBronopol is a preservative sometimes considered as a formaldehyde releaser. It was reported to be an allergen in cosmetics, cleaning agents, dairy workers, and a lubricant jelly used for ultrasound examination.
Safety ProfilePoison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by skin contact. An eye and human skin irritant. An antiseptic. When heated to decomposition it emits very toxic fumes of NOx, and Br-.
SafetyBronopol is used widely in topical pharmaceutical formulations and cosmetics as an antimicrobial preservative.
Although bronopol has been reported to cause both irritant and hypersensitivity adverse reactions following topical use, it is generally regarded as a nonirritant and nonsensitizing material at concentrations up to 0.1% w/v. At a concentration of 0.02% w/v, bronopol is frequently used as a preservative in ‘hypoallergenic’ formulations.
Animal toxicity studies have shown no evidence of phototoxicity or tumor occurrence when bronopol is applied to rodents topically or administered orally; and there is no in vitro or in vivo evidence of mutagenicity; this is despite the demonstrated potential of bronopol to liberate nitrite on decomposition, which in the presence of certain amines may generate nitrosamines. Formation of nitrosamines in formulations containing amines may be reduced by limiting the concentration of bronopol to 0.01% w/v and including an antioxidant such as 0.2% w/v alpha tocopherol or 0.05% w/v butylated hydroxytoluene;(14) other inhibitor systems may also be appropriate.
LD50 (dog, oral): 250 mg/kg
LD50 (mouse, IP): 15.5 mg/kg
LD50 (mouse, IV): 48 mg/kg
LD50 (mouse, oral): 270 mg/kg
LD50 (mouse, SC): 116 mg/kg
LD50 (mouse, skin): 4.75 g/kg
LD50 (rat, IP): 26 mg/kg
LD50 (rat, IV): 37.4 mg/kg
LD50 (rat, oral): 180 mg/kg
LD50 (rat, SC): 170 mg/kg
LD50 (rat, skin): 1.6 g/kg
storageBronopol is stable and its antimicrobial activity is practically unaffected when stored as a solid at room temperature and ambient relative humidity for up to 2 years.
The pH of a 1.0% w/v aqueous solution is 5.0–6.0 and falls slowly during storage; solutions are more stable in acid conditions.
Microbiological assay results indicate longer half-lives than those obtained by HPLC and thus suggest that degradation products may contribute to antimicrobial activity. Formaldehyde and nitrites are among the decomposition products, but formaldehyde arises in such low concentrations that its antimicrobial effect is not likely to be significant. On exposure to light, especially under alkaline conditions, solutions become yellow or brown-colored but the degree of discoloration does not directly correlate with loss of antimicrobial activity.
The bulk material should be stored in a well-closed, nonaluminum container protected from light, in a cool, dry place.
IncompatibilitiesSulfhydryl compounds cause significant reductions in the activity of bronopol, and cysteine hydrochloride may be used as the deactivating agent in preservative efficacy tests; lecithin/polysorbate combinations are unsuitable for this purpose. Bronopol is incompatible with sodium thiosulfate, with sodium metabisulfite, and with amine oxide or protein hydrolysate surfactants. Owing to an incompatibility with aluminum, the use of aluminum in the packaging of products that contain bronopol should be avoided.
Regulatory StatusIncluded in topical pharmaceutical formulations licensed in Europe. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
2-Bromo-2-nitro-1,3-propanediol Preparation Products And Raw materials
Raw materialsMethanol-->Diethyl ether-->Government regulation-->Potassium hydroxide-->Formaldehyde-->Sodium methanolate-->Nitromethane-->Dichloroethane-->1,3-Propanediol
Tag:2-Bromo-2-nitro-1,3-propanediol(52-51-7) Related Product Information
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