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Nitromethane

Nitromethane Basic information
Product Name:Nitromethane
Synonyms:nitromethane E:candyli(at)speedgainpharma(dot)com;NITROMETHANE, 95+%, A.C.S. REAGENT;NITROMETHANE, FOR HPLC;NITROMETHANE, ACS, ABS., OVER MOLECULAR SIEVE (H2O <0.01%);NITROMETHANE, STANDARD FOR GC;NITROMETHANE, 96%, SPECTROPHOTOMETRIC GR ADE;NITROMETHANE, 96+%, HPLC GRADE;NITROMETHANE, REAGENTPLUS, >=99.0%
CAS:75-52-5
MF:CH3NO2
MW:61.04
EINECS:200-876-6
Product Categories:Organics;Analytical Chemistry;Solvents for HPLC & Spectrophotometry;Solvents for Spectrophotometry;Analytical Reagents for General Use;I-N, Puriss p.a.;Puriss p.a.;Reagent Grade Solvents;ReagentSemi-Bulk Solvents;ReagentSolvents;Spectrophotometric Grade Solvents;Spectrophotometric GradeSolvents;ReagentPlus(R) Solvent Grade Products;ReagentPlus(R)Solvents;ACS GradeSolvents;Amber Glass Bottles;Carbon Steel Cans with NPT Threads;Solvent Bottles;ACS and Reagent Grade Solvents;Amber Glass Bottles;ReagentPlus;CHROMASOLV for HPLCSolvents;CHROMASOLV Solvents (HPLC, LC-MS);CHROMASOLV(R) HPLC Grade Solvents;Alpha Sort;N-O;Volatiles/ Semivolatiles;ACS Grade Solvents;ACS GradeSemi-Bulk Solvents;Pharmaceutical intermediates;ReagentPlus Solvent Grade Products;Solvent Bottles;Solvent by Application;Solvent Packaging Options;Solvents;ACS Grade;ACS Grade Solvents;Carbon Steel Cans with NPT Threads;Semi-Bulk Solvents;Anhydrous Solvents;Reagent;Analytical Reagents;Analytical/Chromatography;CHROMASOLV for HPLC;Chromatography Reagents &;HPLC &;HPLC Grade Solvents (CHROMASOLV);HPLC/UHPLC Solvents (CHROMASOLV);UHPLC Solvents (CHROMASOLV)
Mol File:75-52-5.mol
Nitromethane Structure
Nitromethane Chemical Properties
Melting point -29 °C
Boiling point 101.2 °C(lit.)
density 1.127 g/mL at 25 °C(lit.)
vapor density 2.1 (vs air)
vapor pressure 27.3 mm Hg ( 20 °C)
refractive index n20/D 1.382(lit.)
Fp 95 °F
storage temp. Flammables area
solubility 105g/l
pka10.2(at 25℃)
form Liquid
color APHA: ≤10
PH6.4 (0.6g/l, H2O, 20℃)
Relative polarity6.8
explosive limit7.3-63.0%(V)
Water Solubility 9.5 g/100 mL (20 ºC)
λmaxλ: 380 nm Amax: 1.00
λ: 386 nm Amax: 0.50
λ: 395 nm Amax: 0.20
λ: 400 nm Amax: 0.10
λ: 405 nm Amax: 0.05
λ: 430-700 nm Amax: 0.01
Merck 14,6611
BRN 1698205
Henry's Law Constant2.24 at 20.00 °C, 3.61 at 30.00 °C, 5.40 at 40.00 °C, 7.97 at 50.00 °C (inert gas stripping, Bene? and Dohnal, 1999)
Exposure limitsNIOSH REL: IDLH 750 ppm; OSHA PEL: TWA 100 ppm (250 mg/m3); ACGIH TLV: TWA 20 ppm (adopted).
InChIKeyLYGJENNIWJXYER-UHFFFAOYSA-N
CAS DataBase Reference75-52-5(CAS DataBase Reference)
NIST Chemistry ReferenceMethane, nitro-(75-52-5)
EPA Substance Registry SystemMethane, nitro-(75-52-5)
Safety Information
Hazard Codes Xn,F,Xi
Risk Statements 5-10-22
Safety Statements 41
RIDADR UN 1261 3/PG 2
WGK Germany 2
RTECS PA9800000
3-10
Autoignition Temperature784 °F
Hazard Note Irritant/Flammable
TSCA Yes
HazardClass 3
PackingGroup II
HS Code 29042090
Hazardous Substances Data75-52-5(Hazardous Substances Data)
ToxicityLC (in air) in guinea pigs: 1000 ppm; LD50 orally in mice: 1.44 g/kg (Weatherby)
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
Nitromethane Usage And Synthesis
Chemical Propertiesclear liquid
Chemical PropertiesNitromethane is a highly flammable and explosive colorless liquid with a strong, disagreeable odor.
Chemical PropertiesNitromethane is explosive and can be detonated by shock or heat (HSDB 1988) and the chemical can be made more sensitive to detonation through the presence of other chemicals, especially amines and acids. Nitromethane forms salts with inorganic bases and the dry salts are explosive.
Physical propertiesColorless liquid with a strong, disagreeable odor. Odor threshold concentration is 3.5 ppm (quoted, Amoore and Hautala, 1983).
UsesRocket fuel; solvent for zein. Used in the coating industry.
Production MethodsNitromethane and the other important nitroparaffins are synthesized commercially by the vapor-phase nitration of propane (Baker and Bollmeier 1978). At temperatures of 370-450°C and pressures of 8-12 atmospheres, nitromethane, nitroethane and 1- and 2-nitropropane are formed and then separated by distillation.
General DescriptionA colorless oily liquid. Flash point 95°F. May violently decompose if intensely heated when contaminated. Denser than water and slightly soluble in water. Hence sinks in water. Vapors are heavier than air. Moderately toxic. Produces toxic oxides of nitrogen during combustion.
Air & Water ReactionsHighly flammable. Slightly soluble in water.
Reactivity ProfileNitromethane may explode if heated or strongly shocked, especially if mixed with acids, bases [Handling Chemicals Safely 1980. p.687], acetone, aluminum powder, ammonium salts in the presence of organic solvents, haloforms (chloroform, bromoform), or hydrazine in methanol. Ignites on contact with alkyl aluminum or alkyl zinc halides. Reacts violently with strong bases (potassium hydroxide, calcium hydroxide), amines (1,2-diaminoethane, hydrazine), bromine, carbon disulfide, hydrocarbons, formaldehyde, metal oxides, lithium aluminum hydride, sodium hydride, strong oxidizing agents (lithium perchlorate, nitric acid, calcium hypochlorite). Reacts with aqueous silver nitrate to form explosive silver fulminate [Bretherick, 5th ed., 1995, p. 183]. Mixtures of Nitromethane and aluminum chloride may explode when organic matter is present [Chem. Eng. News 26:2257. 1948]. Nitromethane, either alone or in a mixture with methanol and castor oil, has a delayed but violent reaction with powdered calcium hypochlorite [Haz. Home Chem 1963]. Nitromethane reacts violently with hexamethylbenzene [Lewis 2544]. Nitromethane is strongly sensitized by hydrazine [Forshey, D. RR. et al, Explosivestoffe, 1969, 17(6), 125-129].
HazardDangerous fire and explosion risk, lower explosion limit 7.3% in air. Toxic by ingestion and inhalation. Thyroid effects, upper respiratory tract irritant, and lung damage. Possible carcinogen.
Health HazardLiquid may dry out skin and cause irritation.
Health HazardNitromethane is mildly irritating to the skin and mucous membranes (Gosselin et al 1976). It produces narcosis, mucus membrane irritation and central nervous system excitation, and some liver damage. These effects are generally not as marked as after administration of nitroethane. One case of human poisoning has been reported (Kaiffer et al 1972). In that case, a handyman was exposed to high concentrations of nitrocellulose and nitromethane resulting in a 67% conversion of his hemoglobin to methemoglobin and sulfhemoglobin. Treatment with hyperbaric oxygen, transfusion, peritoneal dialysis and then 6 sessions of hemodialysis resulted in recovery.
Fire HazardBehavior in Fire: Containers may explode
Industrial usesNitromethane is used as an intermediate in chemical syntheses, but more importantly it is used as a solvent for coatings and inks. It and the other nitroparaffins are excellent solvents for vinyls, epoxies, polyamides and acrylic polymers (Baker and Bollmeier 1978). It also is used as a military propellant and a racing fuel additive (HSDB 1988). Mixed with methanol and castor oil it is employed as a model airplane fuel.
Safety ProfilePoison by ingestion and intraperitoneal routes. Moderately toxic by intravenous route. Mildly toxic by inhalation. In humans it may cause anorexia, nausea, vomiting, darrhea, kidney injury, and liver damage. exposed to heat, oxidizers, or flame. May explode by detonation, heat, or shock. Its sensitivity is increased when mixed with acids, bases, acetone, aluminum powder, ammonium salts + organic solvents, bis(2- aminoethyl)amine, 1,2-daminoethane + N,2,4,6-tetranitro-N-methyl aniLtne, halo forms (e.g., chloroform, bromoform), hydrazine + methanol. Ignites when mixed with alkyl metal halides (e.g., diethylaluminum bromide, dimethylaluminum bromide, ethylaluminum bromide iodide, methyl zinc iodide, methylaluminum diiodide). Can react violently with AlCl3 + organic matter, Ca(OH)2, m-methyl aniline, Ca(OCl)2, hexamethylbenzene, hydrocarbons, inorganic bases, hydroxides, organic amines, KOH, formaldehyde, nitric acid, metal oxides, 1,2-diaminomethane, litlvum perchlorate, sodium hydride. Reacts with aqueous silver nitrate to form the explosive silver fuhnate. When heated to decomposition it emits toxic fumes of NOx. See also NITROALKANES. A very dangerous fire hazard when exposed to heat, oxidizers, or flame. May explode by detonation, heat, or shock. Its sensitivity is increased when mixed with acids, bases, acetone, aluminum powder, ammonium salts + organic solvents, bis(2- aminoethyl)amine, 1,2-daminoethane + N,2,4,6-tetranitro-N-methyl aniLtne, halo forms (e.g., chloroform, bromoform), hydrazine + methanol. Ignites when mixed with alkyl metal halides (e.g., diethylaluminum bromide, dimethylaluminum bromide, ethylaluminum bromide iodide, methyl zinc iodide, methylaluminum diiodide). Can react violently with AlCl3 + organic matter, Ca(OH)2, m-methyl aniline, Ca(OCl)2, hexamethylbenzene, hydrocarbons, inorganic bases, hydroxides, organic amines, KOH, formaldehyde, nitric acid, metal oxides, 1,2-diaminomethane, litlvum perchlorate, sodium hydride. Reacts with aqueous silver nitrate to form the explosive silver fuhnate. When heated to decomposition it emits toxic fumes of NOx. See also NITROALKANES. concentrated sulfuric acid. When heated to decomposition it emits toxic fumes of NOx. See also NITRO COMPOUNDS and AMINES.
Potential ExposureNitromethane is used in the production of the fumigant, chloropicrin. It is best known as racing car fuel. It is also used as a solvent and as an intermediate in the pharmaceutical industry.
Environmental fateChemical/Physical. Nitromethane will not hydrolyze because it does not contain a hydrolyzable functional group.
MetabolismNitromethane is converted to nitrite and formaldehyde in a 1:1 ratio by hepatic microsomes from phenobarbital-pretreated male Sprague-Dawley rats (Sakurai et al 1980), but no formaldehyde could be detected when microsomes from the nose or liver of untreated male Fischer-344 rats were incubated with nitromethane (Dahl and Hadley 1983). Whether a similar conversion occurs in vivo has not been determined, but the absence of nitromethane metabolism in microsomes from untreated rats suggests that its metabolism in vivo may be slow.
ShippingUN1261 Nitromethane, Hazard Class: 3; Labels: 3-Flammable liquid.
Purification MethodsNitromethane is generally manufactured by gas-phase nitration of methane. The usual impurities include aldehydes, nitroethane, water and small amounts of alcohols. Most of these can be removed by drying with CaCl2 or by distillation to remove the water/nitromethane azeotrope, followed by drying with CaSO4. Phosphorus pentoxide is not suitable as a drying agent. [Wright et al. J Chem Soc 199 1936.] The purified material should be stored by dark bottles, away from strong light, in a cool place. Purifications using extraction are commonly used. For example, Van Looy and Hammett [J Am Chem Soc 81 3872 1959] mixed about 150mL of conc H2SO4 with 1L of nitromethane and allowed it to stand for 1 or 2days. The solvent was washed with water, aqueous Na2CO3, and again with water, then dried for several days with MgSO4, filtered again with CaSO4. It was fractionally distilled before use. Smith, Fainberg and Winstein [J Am Chem Soc 83 618 1961] washed it successively with aqueous NaHCO3, aqueous NaHSO3, water, 5% H2SO4, water and dilute NaHCO3. The solvent was dried with CaSO4, then percolated through a column of Linde type 4A molecular sieves, followed by distillation from some of this material (in powdered form). Buffagni and Dunn [J Chem Soc 5105 1961] refluxed it for 24hours with activated charcoal while bubbling a stream of nitrogen through the liquid. The suspension was filtered, dried (Na2SO4) and distilled, then passed through an alumina column and redistilled. It has also been refluxed over CaH2, distilled and kept under argon over 4A molecular sieves. It has been purified by zone melting at low temperature, or by distillation under vacuum at 0o, subjecting the middle fraction to several freeze-pump-thaw cycles. An impure sample containing higher nitroalkanes and traces of cyanoalkanes was purified (on the basis of its NMR spectrum) by crystallisation from diethyl ether at -60o (cooling in Dry-ice)[Parrett & Sun J Chem Educ 54 448 1977]. Fractional crystallisation is more effective than fractional distillation from Drierite in purifying nitromethane for conductivity measurements. [Coetzee & Cunningham J Am Chem Soc 87 2529 1965.] Specific conductivities around 5 x 10-9 ohm-1cm-1 were obtained. [Beilstein 1 IV 100.]
IncompatibilitiesMay explode from heat, shock, friction, or concussion. Reacts with alkalis, strong acids; metallic oxides. Detonates or reacts violently with strong oxidizers, strong reducing agents such as hydrides; formaldehyde, copper, copper alloys; lead, lead alloys; hydrocarbons and other combustibles, causing fire and explosion hazard. Forms shock sensitive mixture when contaminated with acids, amines, bases, metal oxides; hydrocarbons, and other combustible materials.
Waste DisposalIncineration: large quantities of material may require nitrogen oxide removal by catalytic or scrubbing processes.
Tag:Nitromethane(75-52-5) Related Product Information
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