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Dexmedetomidine

Dexmedetomidine Suppliers list
Company Name: AFINE CHEMICALS LIMITED
Tel: +86-0571-85134551
Email: info@afinechem.com
Products Intro: Product Name:DEXMEDETOMIDINE
Purity:98%+ Package:Standard or custom package Remarks:excellent quality and reliable supplier
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Tel: +8617013299288
Email: dj@sgtlifesciences.com
Products Intro: Product Name:Dexmedetomidine
Company Name: Ontores Biotech  
Tel: 0571-88760729 18072970094
Email: supports@ontorespeptide.com
Products Intro: Product Name:Dexmedetom idine
Purity:98% Package:5mg;100mg;1g,kg
Company Name: Wuhan Yanzhe Technology Co., Ltd  
Tel: 15527250409
Email: wenhaotian12@163.com
Products Intro: Product Name:Dexmedetomidine
Purity:98% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;76g;
Company Name: Shengyang Runze (Beijing) Technology Co.,  
Tel: 010-010-57302162 17611011830
Email: lyt001@syrz01.com
Products Intro: Product Name:DEXMEDETOMIDINE
Purity:99% Package:100g,500g,1kg

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Dexmedetomidine Basic information
Product Name:Dexmedetomidine
Synonyms:
CAS:
MF:C13H16N2
MW:0
EINECS:
Product Categories:
Mol File:Mol File
Dexmedetomidine Structure
Dexmedetomidine Chemical Properties
Melting point 144-147°C
storage temp. -20°C Freezer
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
color White to Off-White
Safety Information
MSDS Information
Dexmedetomidine Usage And Synthesis
DescriptionDexmedetomidine has an eight times increased affinity for the α2-receptor compared with clonidine and therefore produces less cardiovascular instability at comparable doses.
UsesDexmedetomidine is principally used as a sedative in mechanically ventilated patients in ICU. I t is particularly useful in those patients with delirium.
UsesDexmedetomidine is the S -enantiomer of the veterinary anaesthetic medetomidine. It has highly selective activity at α2 adrenoceptors (1600 : 1 α2 : α1) and eight times more affinity than clonidine for this site. D exmedetomidine is licenced in the UK for i.v. sedation of adult patients in intensive care, although there is off-licence use, such as for procedural sedation during an awake craniotomy.
Brand namePrecedex (Hospira).
Mechanism of actionDexmedetomidine is metabolised via hepatic glucuronidation, and clearance is reduced in patients with liver impairment. Very li??le unchanged drug reaches the urine, but 95% of degradation products are excreted this way (4% in faeces). There is a theoretical possibility of accumulation of metabolites in patients with renal failure, but toxicity has not been described because active metabolites of dexmedetomidine have not been identified at present.
PharmacokineticsDexmedetomidine is freely soluble in water and has a pKa of 7.1. The pharmaceutical formulation is a clear, colourless preservative-free solution with a pH of 4.5–8. Protein binding of dexmedetomidine is 94%, with negligible displacement by drugs commonly used in anaesthetic and I CU practice. The elimination half-life is approximately 2h and the steady-state volume of distribution is 118 l. There are no significant differences in the pharmacokinetic profile in the elderly, but an enhanced clinical response is seen.
Veterinary Drugs and TreatmentsIn the USA, dexmedetomidine for dogs is approved for use as a sedative and analgesic to facilitate clinical examinations, clinical procedures, minor surgical procedures, and minor dental procedures, and as a preanesthetic to general anesthesia.
In Europe, dexmedetomidine is additionally indicated for use in cats similarly to dogs above, but when used as premed it is indicated for use prior to ketamine general anesthesia.
Dexmedetomidine Preparation Products And Raw materials
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