| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:CAY10591
CAS:839699-72-8
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
Shanghai Universal Biotech Co.,Ltd
|
| Tel: |
18768175414 |
| Email: |
gaojun@univ-bio.com |
| Products Intro: |
Product Name:CAY10591
CAS:839699-72-8
Package:5mg Remarks: 见优宁维官网
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:CAY10591 Exclusive
CAS:839699-72-8
Purity:98% Package:1mg;5mg;10mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.com |
| Products Intro: |
Product Name:CAY10591
CAS:839699-72-8
Purity:详情请点击官网 Package:1 mg
|
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| | SIRT1 ACTIVATOR 3 Basic information |
| Product Name: | SIRT1 ACTIVATOR 3 | | Synonyms: | SIRT1 ACTIVATOR 3;SIRTUIN 1 ACTIVATOR 3;CAY10591;CAY10591 Exclusive;1H-Pyrrolo[2,3-b]quinoxaline-3-carboxamide, 2-amino-N-cyclopentyl-1-(3-methoxypropyl)- | | CAS: | 839699-72-8 | | MF: | C20H25N5O2 | | MW: | 367.44 | | EINECS: | | | Product Categories: | | | Mol File: | 839699-72-8.mol |  |
| | SIRT1 ACTIVATOR 3 Chemical Properties |
| storage temp. | -20°C | | solubility | Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml). | | form | solid | | color | Olive green | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| | SIRT1 ACTIVATOR 3 Usage And Synthesis |
| Description | SirtAct (839699-72-8) is a Sirt1 activator (233% at 10 μM)1 Suppresses TNFα release from THP-1 cells and stimulates adipogenesis in 3T3L1 cells.1 SIRT1 stimulation by SirtAct leads to decreased tissue factor mediated thrombogenicity in mice.2 SirtAct inhibits NFκB activation and reduces inflammatory cytokine production in lamina propria mononuclear cells from IBD patients.3 Prevents and cures experimental colitis in a mouse model.3 | | Uses | SIRT1 Activator 3 is a SIRT1 activator which also inhibits TNF-α. | | Definition | ChEBI: CAY10591 is a quinoxaline derivative. | | References | 1) Nayagam et al. (2006), SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin sensitizing agents; J. Biomol. Screen., 11 959
2) Barbieri et al. (2012), Cyclooxygenase-2-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor in a sirtuin-1-dependent-manner; Circulation, 126 1373
3) Caruso et al. (2014), Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut; Mucosal Immunol., May 21 Epub. |
| | SIRT1 ACTIVATOR 3 Preparation Products And Raw materials |
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