米诺地尔硫酸盐
中文名称 | 米诺地尔硫酸盐 |
---|---|
中文同义词 | 米诺地乐硫酸盐;敏乐啶硫酸盐;米诺地尔硫酸盐;硫酸敏乐定;硫酸米诺地尔;6-氨基-1,2-二氢-1-羟基-2-亚胺基-4-(1-哌啶基)嘧啶硫酸酯;米诺地尔(硫酸盐)敏乐啶(标准品);6-(1-哌啶基)-2,4-嘧啶二胺-3-氧化物硫酸盐 |
英文名称 | Minoxidil sulphate |
英文同义词 | Sulfuric acid minoxidil;Minoxidil sulfate (U-58838);6-(1-PIPERIDINYL)-2,4-PYRIMIDINEDIAMINE-3-OXIDE SULFATE;MINOXIDIL SULFATE;MINOXIDIL SULPHATE;U-58838;MINOXIDIL SUFATE ETHYLATED;1,6-Dihydro-6-iMino-4-(1-piperidinyl)-1-(sulfooxy)- |
CAS号 | 83701-22-8 |
分子式 | C9H15N5O4S |
分子量 | 289.31 |
EINECS号 | 635-997-7 |
相关类别 | 中间体;抗生素类;原料药;医药原料;降压药;Other APIs;医药原料 血管舒张药;医药原料药;原料中间体-原料药;其他;原料;化工中间体;有机中间体;化工原料;精细化工原料;Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites;Pharmaceuticals;APIs |
Mol文件 | 83701-22-8.mol |
结构式 |
米诺地尔硫酸盐 性质
熔点 | 175-180°C |
---|---|
密度 | 1.75±0.1 g/cm3(Predicted) |
RTECS号 | UV6260494 |
储存条件 | -20°C |
溶解度 | 可溶于丙酮(少许)、DMSO(少许) |
形态 | 白色固体。 |
酸度系数(pKa) | -4.99±0.18(Predicted) |
颜色 | 白色至类白色 |
稳定性 | 光敏性-避光,储存在冰箱中 |
InChI | InChI=1S/C9H15N5O4S/c10-7-6-8(13-4-2-1-3-5-13)12-9(11)14(7)18-19(15,16)17/h6,10H,1-5H2,(H2,11,12)(H,15,16,17) |
InChIKey | AGMYAAIWWVATKU-UHFFFAOYSA-N |
SMILES | C1(N)N(OS(O)(=O)=O)C(=N)C=C(N2CCCCC2)N=1 |
CAS 数据库 | 83701-22-8(CAS DataBase Reference) |
IC50: K channel
Minoxidil sulfate (1-100 μM; 2 hours) significantly reduces the permeability of bloode-brain tumor barrier (BTB) in a monolayer of RBMEC in a time-dependent manner, additionally,the effects of MS on transendothelial electrical resistance (TEER) is Transendothelial electrical resistance (TEER) at 2 h with high concentration.Minoxidil sulfate (0-100 μM; 0-4 hours) increases the RhoA activation in brain tumor tissue by 1 h and the highest level appears at 2 h, it also significantly induces transient PKB phosphorylation at Ser-473, without affecting total PKB levels. Addiotionally, LY294002 partly prevents the phosphorylation of PKB induced by MS.
Western Blot Analysis
Cell Line: | Rat brain microvascular endothelial cells (RBMECs) |
Concentration: | 0-100 μM |
Incubation Time: | 15 mins, 30 mins, 1 hour, 2 hours, 4 hours |
Result: | Induced RhoA activation and PKB phosphorylation at Ser-473. |
Minoxidil sulfate is the active metabolite of Minoxidil and is a potent (IC50=0.14μM) vascular smooth muscle relaxant. Minoxidil sulfate is a selective ATP-sensitive potassium channel opener.
安全信息
危险品标志 | Xn,T+ |
---|---|
危险类别码 | 22-36/37/38-26/27/28 |
安全说明 | 26-36-45-36/37/39-22 |
WGK Germany | 3 |
提供商 | 语言 |
---|---|
英文
|
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-B1445 | Minoxidil sulfate | 25 mg | 750元 | |
2024/08/19 | HY-B1445 | 米诺地尔硫酸盐 Minoxidil sulfate | 83701-22-8 | 10mM * 1mLin DMSO | 825元 |