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| | Amiloride hydrochloride dihydrate Basic information |
| Product Name: | Amiloride hydrochloride dihydrate | | Synonyms: | Modamide;AMILORIDE HYDROCHLORIDE 2-HYDRATE;Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride, dihydrate;AMILORIDE HYDROCHLORIDE (500 MG);AMILORIDEHYDROCHLORIDE,USP;3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide hydrochloride dihydrate;Amiloride hydrochloride dihydrate;Miloride hydrochloride dihydrate | | CAS: | 17440-83-4 | | MF: | C6H8ClN7O.HCl.2H2O | | MW: | 302.12 | | EINECS: | 620-474-8 | | Product Categories: | MK-870 | | Mol File: | 17440-83-4.mol |  |
| | Amiloride hydrochloride dihydrate Chemical Properties |
| Melting point | >240℃ | | RTECS | UQ2275500 | | storage temp. | Store at -20°C | | solubility | Slightly soluble in water and in anhydrous ethanol. | | pka | 8.7(at 25℃) | | form | Solid | | color | Off-white to yellow | | Water Solubility | Soluble in water at 50mg/ml | | Major Application | pharmaceutical | | InChI | InChI=1S/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2 | | InChIKey | LTKVFMLMEYCWMK-UHFFFAOYSA-N | | SMILES | C1(C(NC(N)=N)=O)=NC(Cl)=C(N)N=C1N.[H]Cl.[H]O[H].[H]O[H] |
| WGK Germany | 3 | | HazardClass | 6.1 | | HS Code | 2933995300 | | Storage Class | 11 - Combustible Solids |
| | Amiloride hydrochloride dihydrate Usage And Synthesis |
| Chemical Properties | Pale yellow or greenish-yellow powder. | | Uses | An epithelial sodium channel blocker | | Uses | Diuretic;Antialdosteron | | Uses | Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 M. Amiloride HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator. | | Definition | ChEBI: A hydrate that is the dihydrate of amiloride hydrochloride. | | Brand name | Midamor (Merck). | | in vivo | Amiloride hydrochloride dihydrate is a potent epithelial sodium channels (ENaCs) blocker. Amiloride is highly concentrated in the plasma 15 to 30 minutes following the injections. 2 mg/kg dose of Amiloride hydrochloride dihydrate has no effect on blood pressure, heart rate, mesenteric vascular resistance, or hindquarters vascular resistance as compare to the baseline measurements (n=7). Over a 2 hour period, Amiloride hydrochloride dihydrate elicits negligible responses in arterial pressure (-1±1 mmHg) and heart rate (-10±6 bpm/min) as compare to baseline levels. Results show an Amiloride hydrochloride dihydrate dose-related response pattern for the c-Fos activation in the area postrema (AP). Even at the lowest dose of Amiloride hydrochloride dihydrate (0.1 mg/kg), the number of c-Fos labeled neurons in the AP is statistically different from the control rats at a p<0.01 level[1]. |
| | Amiloride hydrochloride dihydrate Preparation Products And Raw materials |
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