What is the mechanism that causes paclitaxel resistance?

The mechanisms for resistance to paclitaxel have also been extensively investigated, such as ABC transporter overexpression, altered signaling apoptotic gene expression to resist cell death, changes associated with microtubules to reduce influences drugs. Meanwhile, another important mechanism paclitaxel resistance has been proposed: increased nuclear lamina/envelope sturdiness to retard breaking nuclear envelop paclitaxel-induced multinucleation as well as formation multiple micronuclei.

References:

[1] ELIZABETH R. SMITH . Paclitaxel resistance related to nuclear envelope structural sturdiness[J]. Drug Resistance Updates, 2022, 65: Article 100881. DOI:10.1016/j.drup.2022.100881.