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ChemicalBook >> CAS DataBase List >> Alectinib

Alectinib

Alectinib price.
  • $35 - $1504.5
  • Product name: Alectinib
  • CAS: 1256580-46-7
  • MF: C30H34N4O2
  • MW: 482.62
  • EINECS:821-541-6
  • MDL Number:MFCD19440988
  • Synonyms:AF-802;CH-5424802/RG-7853;Alectinib;AF-802,RG-7853;9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile Alectinib (CH5424802);CH5424802-alectinib;9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile CH5424802;CH5424802, Alectinib, AF802
25 prices
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Brand
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • TRC
Package
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  • 5mg
  • 10mg
  • 20mg
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  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 1g
  • 1000mg
  • ManufacturerAK Scientific
  • Product numberY0295
  • Product descriptionCH5424802
  • Packaging100mg
  • Price$211
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8393
  • Product descriptionCH5424802
  • Packaging5mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8393
  • Product descriptionCH5424802
  • Packaging50mg
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60105
  • Product descriptionAlectinib(CH5424802) ≥98%
  • Packaging20mg
  • Price$258
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3370B
  • Product descriptionAlectinib
  • Packaging5mg
  • Price$35
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3370B
  • Product descriptionAlectinib
  • Packaging25mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3370B
  • Product descriptionAlectinib
  • Packaging100mg
  • Price$135
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3370B
  • Product descriptionAlectinib
  • Packaging1g
  • Price$275
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181220
  • Product descriptionCH5424802(Alectinib) >99%
  • Packaging100mg
  • Price$510
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181220
  • Product descriptionCH5424802(Alectinib) >99%
  • Packaging250mg
  • Price$765
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181220
  • Product descriptionCH5424802(Alectinib) >99%
  • Packaging1000mg
  • Price$1504.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18516
  • Product descriptionCH5424802 ≥95%
  • Packaging1mg
  • Price$49
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18516
  • Product descriptionCH5424802 ≥95%
  • Packaging5mg
  • Price$202
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18516
  • Product descriptionCH5424802 ≥95%
  • Packaging10mg
  • Price$310
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0518
  • Product descriptionAlectinib 99.87%
  • Packaging5mg
  • Price$72
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0518
  • Product descriptionAlectinib 99.87%
  • Packaging10mg
  • Price$90
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific Y0295 CH5424802 100mg $211 2021-12-16 Buy
ApexBio Technology A8393 CH5424802 5mg $90 2021-12-16 Buy
ApexBio Technology A8393 CH5424802 50mg $250 2021-12-16 Buy
Arctom CFN60105 Alectinib(CH5424802) ≥98% 20mg $258 2021-12-16 Buy
AvaChem 3370B Alectinib 5mg $35 2021-12-16 Buy
AvaChem 3370B Alectinib 25mg $75 2021-12-16 Buy
AvaChem 3370B Alectinib 100mg $135 2021-12-16 Buy
AvaChem 3370B Alectinib 1g $275 2021-12-16 Buy
Biorbyt Ltd orb181220 CH5424802(Alectinib) >99% 100mg $510 2021-12-16 Buy
Biorbyt Ltd orb181220 CH5424802(Alectinib) >99% 250mg $765 2021-12-16 Buy
Biorbyt Ltd orb181220 CH5424802(Alectinib) >99% 1000mg $1504.5 2021-12-16 Buy
Cayman Chemical 18516 CH5424802 ≥95% 1mg $49 2024-03-01 Buy
Cayman Chemical 18516 CH5424802 ≥95% 5mg $202 2024-03-01 Buy
Cayman Chemical 18516 CH5424802 ≥95% 10mg $310 2024-03-01 Buy
ChemScene CS-0518 Alectinib 99.87% 5mg $72 2021-12-16 Buy
ChemScene CS-0518 Alectinib 99.87% 10mg $90 2021-12-16 Buy

Properties

Melting point :274-276°C
Boiling point :722.5±60.0 °C(Predicted)
Density :1.28
storage temp. :-20°
solubility :Soluble in DMSO (up to 5 mg/ml with warming).
form :solid
pka :13.70±0.40(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions are not stable and should be prepared fresh daily.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P314 Get medical advice/attention if you feel unwell.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that promotes cell proliferation and blocks apoptosis. CH5424802 is an ATP-competitive inhibitor of ALK (IC50 = 1.9 nM) that also inhibits F1174L, R1275Q, and L1196M mutants of ALK (IC50s = 1.0, 3.5, and 1.6 nM, respectively). It shows more than 500-fold selectivity for ALK over a panel of 24 other kinases. CH5424802 is orally available and inhibits the growth of tumors in mouse xenograft models of nonsmall cell lung cancer and anaplastic large-cell lymphoma.

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