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ChemicalBook >> CAS DataBase List >> EAI-045

EAI-045

EAI-045 price.
  • $7 - $1575
  • Product name: EAI-045
  • CAS: 1942114-09-1
  • MF: C19H14FN3O3S
  • MW: 383.4
  • EINECS:-0
  • MDL Number:MFCD30187871
  • Synonyms:EAI-045;2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide;EA1045;α-(5-fluoro-2-hydroxyphenyl)-1,3-dihydro-1-oxo-N-2-thiazolyl-2H-Isoindole-2-acetamide;EAI 045;EAI-045;CS-2350;EAI045;EAI 045;EAI-045;N-(3-((5-fluoroethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide (EAI-045)
Price28 Properties Safety Information Description
28 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • AvaChem
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Medical Isotopes, Inc.
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 5g
  • ManufacturerAK Scientific
  • Product number5125EG
  • Product descriptionCID121231412
  • Packaging10mg
  • Price$185
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105328
  • Product description2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97%
  • Packaging5mg
  • Price$7
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105328
  • Product description2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97%
  • Packaging10mg
  • Price$10
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105328
  • Product description2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97%
  • Packaging25mg
  • Price$14
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105328
  • Product description2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97%
  • Packaging50mg
  • Price$20
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105328
  • Product description2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97%
  • Packaging100mg
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105328
  • Product description2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97%
  • Packaging250mg
  • Price$44
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105328
  • Product description2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97%
  • Packaging1g
  • Price$109
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA105328
  • Product description2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97%
  • Packaging5g
  • Price$376
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0004748
  • Product descriptionALPHA-(5-FLUORO-2-HYDROXYPHENYL)-1,3-DIHYDRO-1-OXO-N-2-THIAZOLYL-2H-ISOINDOLE-2-ACETAMIDE 95.00%
  • Packaging5MG
  • Price$505.05
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6054
  • Product descriptionEAI045
  • Packaging10mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6054
  • Product descriptionEAI045
  • Packaging25mg
  • Price$330
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6054
  • Product descriptionEAI045
  • Packaging100mg
  • Price$980
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3368
  • Product descriptionEAI450
  • Packaging5mg
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3368
  • Product descriptionEAI450
  • Packaging25mg
  • Price$275
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3368
  • Product descriptionEAI450
  • Packaging100mg
  • Price$575
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 5125EG CID121231412 10mg $185 2021-12-16 Buy
Ambeed A105328 2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97% 5mg $7 2021-12-16 Buy
Ambeed A105328 2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97% 10mg $10 2021-12-16 Buy
Ambeed A105328 2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97% 25mg $14 2021-12-16 Buy
Ambeed A105328 2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97% 50mg $20 2021-12-16 Buy
Ambeed A105328 2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97% 100mg $30 2021-12-16 Buy
Ambeed A105328 2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97% 250mg $44 2021-12-16 Buy
Ambeed A105328 2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97% 1g $109 2021-12-16 Buy
Ambeed A105328 2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide 97% 5g $376 2021-12-16 Buy
American Custom Chemicals Corporation INB0004748 ALPHA-(5-FLUORO-2-HYDROXYPHENYL)-1,3-DIHYDRO-1-OXO-N-2-THIAZOLYL-2H-ISOINDOLE-2-ACETAMIDE 95.00% 5MG $505.05 2021-12-16 Buy
ApexBio Technology B6054 EAI045 10mg $200 2021-12-16 Buy
ApexBio Technology B6054 EAI045 25mg $330 2021-12-16 Buy
ApexBio Technology B6054 EAI045 100mg $980 2021-12-16 Buy
AvaChem 3368 EAI450 5mg $105 2021-12-16 Buy
AvaChem 3368 EAI450 25mg $275 2021-12-16 Buy
AvaChem 3368 EAI450 100mg $575 2021-12-16 Buy
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Properties

Density :1.546±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :≥38.3 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :7.20±0.50(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

EAI045 is a potent and selective EGFR inhibitor (fourth generation). EAI045 targets selected drug-resistant EGFR mutants without affecting the wild-type receptor. EAI045 inhibits L858R/T790M-mutant EGFR with low-nanomolar potency in biochemical assays. Therefore, it is a potential candidate drug for the treatment of related non-small cell lung cancer (NSCLC). It should be noted that EAI-045 is effectively in targeting the EGFR C797S mutation, which is resistance to the third-generation EGFR inhibitors including AZD9291 (osimertinib) and CO-1686 (rociletinib).

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Suppliers and manufacturers

career henan chemical co
EAI-045
$9.80 /1.79999995231628KG
EAI-045 CAS:1942114-09-1
Nanjing Gold Pharmaceutical Technology Co. Ltd.
Beijing Cooperate Pharmaceutical Co.,Ltd
ATK CHEMICAL COMPANY LIMITED
Zhejiang ZETian Fine Chemicals Co. LTD
Biochempartner
BOC Sciences
Jurong Coupling Biotechnology Co., Ltd.
ANHUI WITOP BIOTECH CO., LTD
AFINE CHEMICALS LIMITED