盐酸丁双胍
中文名称 | 盐酸丁双胍 |
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中文同义词 | 盐酸丁双胍;盐酸丁二胍/盐酸丁福明;盐酸丁二胍;盐酸丁福明;丁福明盐酸盐;正丁基亚胺基二碳亚胺二酰胺盐酸盐;盐酸丁双胍 标准品;丁双胍盐酸盐 |
英文名称 | BuforMin Hydrochloride |
英文同义词 | 1-Butylbigyanidine hydrochloride;1-Butylbiguanide Hydrochloride;N-ButylidodicarboniMidic DiaMide Hydrochloride;PanforMin;Sindiatil;TideMol;Ziavetine;Adebit |
CAS号 | 1190-53-0 |
分子式 | C6H16ClN5 |
分子量 | 193.68 |
EINECS号 | 214-723-6 |
相关类别 | 对照品;Amines;Intermediates & Fine Chemicals;Pharmaceuticals |
Mol文件 | 1190-53-0.mol |
结构式 |
盐酸丁双胍 性质
熔点 | 177-179?C |
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储存条件 | Inert atmosphere,Store in freezer, under -20°C |
溶解度 | DMSO(少许)、甲醇(少许)、水(少许) |
形态 | 固体 |
颜色 | 白色至类白色 |
稳定性 | 吸湿性 |
CAS 数据库 | 1190-53-0 |
Buformin hydrochloride (0-10 mM; 5 days) inhibits SKBR3 and BT474 cells growth as a concentration-dependent manner, exhibits IC 50 values of 246.7 μM and 98.6 μM for erbB-2-overexpressing SKBR3 and BT474 cells, respectively.Buformin hydrochloride (0-3 mM; 48 hours) increases the percentage of cells in G0/G1 phase and reduced the percentage of cells in S phase, especially in the SKBR3 cells.Buformin hydrochloride (0-3 mM; 24 hours) suppresses RTK activation, including erbB-2 and IGF1R signaling downstream, and Akt activation/phosphorylation is inhibited in both SKBR3 and BT474 cells.
Cell Viability Assay
Cell Line: | ErbB-2-overexpressing SKBR3 and BT474 cells |
Concentration: | 0 μM, 1 μM, 3 μM, 10 μM, 30 μM, 100 μM, 300 μM, 1, 3, or 10 mM |
Incubation Time: | 5 days |
Result: | Reduced cell viability in erbB-2-overexpressing breast cells. |
Cell Cycle Analysis
Cell Line: | ErbB-2-overexpressing SKBR3 and BT474 cells |
Concentration: | 0.5 mM; 1 mM; 3 mM |
Incubation Time: | 48 hours |
Result: | Increased cells arresting in G0/G1 phase. |
Western Blot Analysis
Cell Line: | ErbB-2-overexpressing SKBR3 and BT474 cells |
Concentration: | 0 mM, 0.1 mM, 0.3 mM, 1 mM, or 3 mM |
Incubation Time: | 24 hours |
Result: | Decreased p-AMPK, p-p706S, p-ERK1/2 expression in a concentration-dependent manner. |
Buformin hydrochloride (oral administation; 7.6 mmol/kg of chow; 7 days) exhibits significantly reduced tumor volumes and weights, and hinders mammary morphogenesis and proliferation in MMTV-erbB-2 transgenic mice.
Animal Model: | Female MMTV-erbB-2 transgenic mice |
Dosage: | 7.6 mmol/kg |
Administration: | Oral administation; 7 days |
Result: | Inhibited mammary syngeneic tumor growth in MMTV-erbB-2 transgenic mice. |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-B2099A | Buformin hydrochloride | 50 mg | 800元 | |
2024/08/19 | HY-B2099A | 盐酸丁双胍 Buformin hydrochloride | 1190-53-0 | 100mg | 1200元 |