ChemicalBook CAS DataBase List 1,3-Bis(diphenylphosphino)propane

1,3-Bis(diphenylphosphino)propane synthesis

9synthesis methods

Product Name:1,3-Bis(diphenylphosphino)propane
CAS Number:6737-42-4
Molecular formula:C27H26P2
Molecular Weight:412.45

3-(diphenylphosphoryl)propyl(diphenyl)phosphine oxide

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Yield:6737-42-4 80%

Reaction Conditions:

with indium(III) bromide;1,1,3,3-Tetramethyldisiloxane in toluene at 100; for 22 h;Inert atmosphere;Sealed tube;

Steps:

General procedure for the preparation of compounds 2a, 2g and 2h.
General procedure: In a sealed tube containing a solution of the phosphine oxide derivative (5 mmol) in anhydrous toluene (1M) was added InBr₃ (1 mol %, 0.05 mmol) and the TMDS (1.5 equiv., 7.5 mmol). The reactionnal mixture was stirred at 100 °C during 7 to 40 h depending on the substrate (the reaction was monitored by ³¹P NMR). After complete consumption and evaporation of toluene the phosphine was purified by flash chromatography on silica gel with pure cyclohexane) to afford the desired phosphine.

References:

Pehlivan, Leyla;Métay, Estelle;Delbrayelle, Dominique;Mignani, Gérard;Lemaire, Marc [Tetrahedron,2012,vol. 68,# 15,p. 3151 - 3155] Location in patent:supporting information; experimental part

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109-64-8 Synthesis