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Diphenylphosphine oxide

Diphenylphosphine oxide Structure
Diphenylphosphine oxide structure
CAS No.
4559-70-0
Chemical Name:
Diphenylphosphine oxide
Synonyms
DPPO;HPOPh2;Diphenylphosphinoxid;GC-DPO;AURORA KA-1314;Diphenylphosphinit;Diphenylphosphorus;TIMTEC-BB SBB005946;Diphenylphosphaneoxide;DIPHENYLPHOSPHINE OXIDE
CBNumber:
CB1471001
Molecular Formula:
C12H11OP
Molecular Weight:
202.19
MDL Number:
MFCD00002079
MOL File:
4559-70-0.mol
MSDS File:
SDS
Last updated:2026-03-20 10:09:07
Product description Number Pack Size Price
Diphenylphosphine oxide 97% 287881 1g $85.7
Diphenylphosphine oxide 97% 287881 5g $186
Diphenylphosphine Oxide >98.0%(GC) D2826 5g $146
Diphenylphosphine Oxide >98.0%(GC) D2826 25g $501
Diphenylphosphine oxide 273793 1g $347
More product size
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Diphenylphosphine oxide Properties

Melting point 56-57 °C(lit.)
Boiling point 102-105°C 0,2mm
refractive index 1.608-1.61
storage temp. Inert atmosphere,Room Temperature
form Crystals
color Yellow to light orange
Water Solubility Slightly soluble in water.
Sensitive Moisture Sensitive
InChI InChI=1S/C12H11OP/c13-14(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,14H
InChIKey ASUOLLHGALPRFK-UHFFFAOYSA-N
SMILES P(=O)(C1=CC=CC=C1)C1=CC=CC=C1
CAS DataBase Reference 4559-70-0(CAS DataBase Reference)
FDA UNII XXW49HG6X3
UNSPSC Code 12352002
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26
WGK Germany  2
HS Code  29319090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

Diphenylphosphine oxide price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 287881 Diphenylphosphine oxide 97% 4559-70-0 1g $85.7 2026-03-19 Buy
Sigma-Aldrich 287881 Diphenylphosphine oxide 97% 4559-70-0 5g $186 2026-03-19 Buy
TCI Chemical D2826 Diphenylphosphine Oxide >98.0%(GC) 4559-70-0 5g $146 2026-03-19 Buy
TCI Chemical D2826 Diphenylphosphine Oxide >98.0%(GC) 4559-70-0 25g $501 2026-03-19 Buy
Usbiological 273793 Diphenylphosphine oxide 4559-70-0 1g $347 2021-12-16 Buy
Product number Packaging Price Buy
287881 1g $85.7 Buy
287881 5g $186 Buy
D2826 5g $146 Buy
D2826 25g $501 Buy
273793 1g $347 Buy

Diphenylphosphine oxide Chemical Properties,Uses,Production

Chemical Properties

Yellow to light orange crystals

Uses

Used in the preparation of triarylphosphine oxides, and as asymmetric catalysts, preparation of alkenyldiphenylphosphine oxides, and Horner-Wittig reagents. It is a ligand for Buchwald-Hartwig Cross Coupling Reaction, Hydrophosphonylations and Suzuki-Miyaura Coupling.

Uses

suzuki reaction

Definition

ChEBI: Diphenylphosphine oxide is a member of benzenes.

Synthesis Reference(s)

Journal of the American Chemical Society, 45, p. 165, 1923 DOI: 10.1021/ja01654a024

reaction suitability

reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: Hydrophosphonylations
reagent type: ligand
reaction type: Suzuki-Miyaura Coupling

Synthesis

There are three main methods for the synthesis of diphenylphosphine oxide. Method 1 is to use POCl3 as raw material, after Foucault alkylation reaction, lithium aluminum hydride reduction to get the target; method 2 is to use diethyl phosphite as raw material, the reaction of Gram's reagent to generate the product; method 3 by Miller et al. to use PCl3 as raw material, after Foucault alkylation reaction, and then the target by the appropriate hydrolysis, but its intermediate Ph2PCl purification is more difficult, and the yield is low, only 37.0%. only 37.0%.

Diphenylphosphine oxide Preparation Products And Raw materials

Raw materials

Ethanol Sodium Bromobenzene Phosphorus trichloride Tetrahydrofuran
Ethyl acetate Diethyl phosphite Hydrochloric acid Dichloromethane Sodium hydroxide
PETROLEUM ETHER Magnesium Lithium

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Preparation Products

1,2-BIS(DIPHENYLPHOSPHINOMETHYL)BENZENE 2-(Diphenylphosphino)-biphenyl (DIPHENYLPHOSPHORYL)METHANOL (3R-trans)-[2-[3,5-Bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]cyclohexylidene]ethyl]diphenyl-phosphine Oxide

Diphenylphosphine oxide Suppliers

Global( 382)Suppliers
Supplier Tel Email Country ProdList Advantage
Guangzhou Xijia New Materials Co.,Ltd
+undefined13650882421 ebswax@163.com China 21 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20124 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 3692 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		+86-15350851019; +8615350851019 admin@86-ss.com China 999 58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-13017695106 +86-13676922317 jiuyitime@fdachem.com China 16513 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21592 55
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1803 55
Supplier Advantage
Guangzhou Xijia New Materials Co.,Ltd
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Henan Fengda Chemical Co., Ltd 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Time Chemicals CO., Ltd. 		55

Related articles

View Lastest Price from Diphenylphosphine oxide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Diphenylphosphine oxide pictures 2026-04-17 Diphenylphosphine oxide
4559-70-0
 US $1.10-9.90 / KG 1KG 99%min 100KG ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Diphenylphosphine oxide pictures 2026-04-17 Diphenylphosphine oxide
4559-70-0
 US $100.00-75.00 / kg 1kg 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Diphenylphosphine oxide pictures 2026-03-20 Diphenylphosphine oxide
4559-70-0
 US $0.00 / KG 1KG 99% 10000KG Guangzhou Xijia New Materials Co.,Ltd

Diphenylphosphine oxide Spectrum

Diphenylphosphine oxide(4559-70-0)1HNMRDiphenylphosphine oxide(4559-70-0)RamanDiphenylphosphine oxide(4559-70-0)IR

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