ChemicalBook CAS DataBase List 1-[4-(ALLYLOXY)PHENYL]ETHANONE

1-[4-(ALLYLOXY)PHENYL]ETHANONE synthesis

10synthesis methods

Product Name:1-[4-(ALLYLOXY)PHENYL]ETHANONE
CAS Number:2079-53-0
Molecular formula:C11H12O2
Molecular Weight:176.21

106-95-6 Synthesis

106-95-6
411 suppliers
$10.00/5g

99-93-4 Synthesis

99-93-4
817 suppliers
$5.00/25g

2079-53-0
15 suppliers
$45.00/100mg

Yield:2079-53-0 100%

Reaction Conditions:

with potassium carbonate in acetone at 20;Reflux;

Steps:

153.153-a-1

Example 153; Preparation of 3-((4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-propylphenoxy)pyridin-2-yl) methyl)-5-methyl-5-(2-methyl-2,3-dihydrobenzofuran-5-yl)imidazolidine-2,4-dione; 153-a-1) Preparation of 1-(4-(allyloxy)phenyl)ethanone; 2-Hydroxyacetophenone (1.36 g, 10.0 mmol) was dissolved in acetone (50 mL). The resultant mixture was added with potassium carbonate (2.76 g, 20.0 mmol) and allylbromide (1.27 mL, 15.0 mmol) at room temperature and heated to reflux for 3 hours. The reaction solution was cooled to room temperature, added with ethyl acetate, and washed with water and brine. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo. The obtained residue was purified using silica-gel column chromatography (n-hexane/ethyl acetate=10/1). 1-(4-(Allyloxy)phenyl)ethanone (1.76 g, 100%) was obtained as a colorless oil.¹H-NMR (CDCl₃) δ: 2.56 (3H, s), 4.60-4.62 (2H, m), 5.31-5.45 (2H, m), 6.00-6.09 (1H, m), 6.93-6.97 (2H, m), 7.92-7.95 (2H, m).

References:

US2010/48610,2010,A1 Location in patent:Page/Page column 85-86