1,4-di(furan-2-yl)benzene synthesis
- Product Name:1,4-di(furan-2-yl)benzene
- CAS Number:34121-64-7
- Molecular formula:C14H10O2
- Molecular Weight:210.23
106-37-6
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Yield:34121-64-7 91%
Reaction Conditions:
Stage #1: 1.4-dibromobenzene;tetrakis(triphenylphosphine) palladium(0) for 0.25 h;
Stage #2: 2-(tributylstannyl)furan at 100; for 24 h;
Steps:
3
2-(4-Furan-2-yl-phenyl)-furan (15); To a stirred solution of 1,4-dibromobenzene (5 mmol) was added palladium tetrakis-triphenylphosphine (400 mg). The reaction mixture was kept stirring for 15 min after which 2-tributylstannylfuran (10 mmol) was added and the reaction mixture was refluxed at 100 °C for 24 h. The solvent was then evaporated to dryness to give a dark brown residue that was suspended in water and extracted with CH2Cl2. The organic layer was passed over hyflo, dried (Na2SO4) and evaporated to dryness under reduced pressure to give 15 in 91% yield; mp 149-150 °C. 1H NMR (DMSO-d6); δ 6.62 (d, 2H), 7.01 (d, 2H), 7.76-7.79 (m, 6H). MS (ESI) m/e (rel. int.): 210 (M+, 100), 181 (40), 153 (30). Anal. Calc. for C14H10O2: C% 79.98; H% 4.79; Found C% 80.12; H% 4.59.
References:
EP1736466,2006,A1 Location in patent:Page/Page column 37
13331-23-2
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106-37-6
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624-38-4
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118486-94-5
125 suppliers
$32.00/5ml
34121-64-7
13 suppliers
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