1,4-DI-TERT-BUTYL-2,5-DIMETHOXYBENZENE synthesis
- Product Name:1,4-DI-TERT-BUTYL-2,5-DIMETHOXYBENZENE
- CAS Number:7323-63-9
- Molecular formula:C16H26O2
- Molecular Weight:250.38
88-58-4
424 suppliers
$7.00/25g
74-88-4
355 suppliers
$15.00/10g
7323-63-9
116 suppliers
$5.00/250mg
Yield:7323-63-9 94%
Reaction Conditions:
Stage #1: 2,5-bis(1,1-dimethylethyl)-1,4-benzenediolwith sodium hydride in N,N-dimethyl-formamide at 20; for 0.25 h;Inert atmosphere;
Stage #2: methyl iodide in N,N-dimethyl-formamide at 40; for 2 h;Inert atmosphere;Reagent/catalyst;Solvent;Temperature;
Steps:
1.2; 2.2; 3.2; 4.2; 5.2 (2) Preparation 2,5-Di-tert-butyl terephthalate
Dissolve 44.5g (0.2mol) of 2,5-di-tert-butylhydroquinone prepared in step (1) in 500g DMF, add 0.46g (19mmol) of sodium hydride under the protection of nitrogen, and stir for 15min at room temperature. Warm up to 40°C, slowly add 50ml (0.8mmol) methyl iodide dropwise, maintain the reaction temperature at 40°C, react for 2h, allow the system to cool to room temperature, slowly add 200g saturated brine to stop the reaction, the resulting mixture is extracted three times with 100g ethyl acetate The organic layer was washed three times with 100 ml of clear water and dried in vacuum to obtain 47 g of 2,5-di-tert-butyl terephthalate, with a yield of 94% and a total yield of 91%
References:
CN112876342,2021,A Location in patent:Paragraph 0033; 0036-0038; 0041-0043; 0046-0048; 0051-0053
150-78-7
542 suppliers
$5.00/25g
75-65-0
778 suppliers
$10.00/10ml
7323-63-9
116 suppliers
$5.00/250mg
150-78-7
542 suppliers
$5.00/25g
7323-63-9
116 suppliers
$5.00/250mg
88-58-4
424 suppliers
$7.00/25g
77-78-1
327 suppliers
$22.00/25g
7323-63-9
116 suppliers
$5.00/250mg
1991-52-2
42 suppliers
$60.00/1g
77-78-1
327 suppliers
$22.00/25g
7323-63-9
116 suppliers
$5.00/250mg