1-(BENZYLOXY)-4-(2,2,2-TRIFLUOROETHOXY)BENZENE synthesis
- Product Name:1-(BENZYLOXY)-4-(2,2,2-TRIFLUOROETHOXY)BENZENE
- CAS Number:200956-20-3
- Molecular formula:C15H13F3O2
- Molecular Weight:282.26
Yield:200956-20-3 100%
Reaction Conditions:
with caesium carbonate in acetonitrile at 85; for 3 h;Inert atmosphere;
Steps:
In a high pressure flask was charged 4-(benzyloxy)phenol (0.30 g, 1.5 mmol), cesium carbonate (0.49 g, 1.5 mmol), 2,2,2-trifluoroethyl trifluoromethanesulfonate (0.32 mL, 2.25 mmol) and dry acetonitrile (7.5 mL). The flask was flushed with N2 for 5 minutes, capped and heated at 85 °C (bath temperature) for 3.0 h. After cooling to r.t., the solid was filtered off and the filtrate was diluted with ethyl acetate and washed with brine three times. The organic phase was dried over anhydrous Na2SO4, filtered and concentrated. The residue was purified by column chromatography (10% ethyl acetate/hexanes) to give a white solid
References:
Yang, Qingliang;Njardarson, Jon T. [Tetrahedron Letters,2013,vol. 54,# 51,p. 7080 - 7082] Location in patent:supporting information
