1-(BENZYLOXY)-4-BROMO-2-METHOXYBENZENE synthesis
- Product Name:1-(BENZYLOXY)-4-BROMO-2-METHOXYBENZENE
- CAS Number:63057-72-7
- Molecular formula:C14H13BrO2
- Molecular Weight:293.16
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Yield: 100%
Reaction Conditions:
with caesium carbonate in acetone for 4 h;Heating / reflux;
Steps:
35 1-Benzyloxy-4-bromo-2-methoxy-benzene
Preparation 35 1-Benzyloxy-4-bromo-2-methoxy-benzene A mixture of 4-bromo-2-methoxyphenol (5 g, 24.63 mmol), benzyl bromide (4.21 g, 24.63 mmol) and cesium carbonate (8 g, 24.63 mmol) in acetone (60 mL) were heated under reflux for 4 hours. The cooled reaction mixture was then evaporated under reduced pressure and the residue was partitioned between diethyl ether (200 mL) and water (80 mL). The aqueous phase was separated and re-extracted with diethyl ether (200 mL). The combined organic extracts were dried over magnesium sulfate and concentrated in vacuo. The residue was azeotroped with dichloromethane to afford the title compound as white solid in 100% yield, 7.19 g. LRMS (ES+): m/z [M+Na]+ 317
References:
PFIZER INC. US2005/43300, 2005, A1 Location in patent:Page/Page column 39
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63057-72-7
47 suppliers
$13.00/250mg