1-Boc-4-(2-thioxopiperidin-1-ylMethyl)piperidine synthesis
- Product Name:1-Boc-4-(2-thioxopiperidin-1-ylMethyl)piperidine
- CAS Number:184968-86-3
- Molecular formula:C16H28N2O2S
- Molecular Weight:312.47
184968-83-0
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184968-86-3
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Yield:184968-86-3 82%
Reaction Conditions:
with Lawessons reagent in tetrahydrofuran at 23; for 20 h;
Steps:
2.3.2C Prep. 2C:
Combine the product (1.50 g, 5.06 mmol) of Prep. 2A and Lawesson reagent (1.13 g, 2.78 mmol) in dry THF (20 mL) under N2. Stir at 23°C for 20 h. Concentrate and purify by chromatography (200 mL of flash silica gel; eluant: 1:3 EtOAc:hexane, 1:2 EtOAc:hexane, then 1:1 EtOAc:hexane). Combine appropriate fractions and concentrate to give 1.30 g (4.16 mmol, 82%) as a green oil. MS (FAB): m/e 313 (M+1).
References:
EP1032561,2004,B1 Location in patent:Page 12
6457-49-4
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24424-99-5
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123855-51-6
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