ChemicalBook CAS DataBase List 2-(3-broMo-5-chlorophenyl)-4,6-diphenyl-1,3,5-triazine

2-(3-broMo-5-chlorophenyl)-4,6-diphenyl-1,3,5-triazine synthesis

5synthesis methods

Product Name:2-(3-broMo-5-chlorophenyl)-4,6-diphenyl-1,3,5-triazine
CAS Number:1073062-42-6
Molecular formula:C21H13BrClN3
Molecular Weight:422.7

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2-(3-broMo-5-chlorophenyl)-4,6-diphenyl-1,3,5-triazine

1073062-42-6
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Yield: 87%

Reaction Conditions:

Stage #1:3-bromo-5-chloro-benzaldehyde;benzamidine monohydrochloride with potassium phosphate in dimethyl sulfoxide at 90; for 1 h;
Stage #2: with magnesium sulfate;2,3-dicyano-5,6-dichloro-p-benzoquinone in tetrahydrofuran;dimethyl sulfoxide at 20; for 0.166667 h;

Steps:

1.1
3-bromo-5-chlorobenzaldehyde (30 g, 136.7 mmol), Benzamidine Hydrochloride (42.8 g, 273.4 mmol), K3PO4 (58.0 g, 273.4 mmol) in dimethylsulfoxide (DMSO) to put the mixture 90°C for 1 hour It was heated. After the reaction was complete, add water to the reaction mixture produced by the solid was filtered to obtain a solid of a pale yellow. This, tetrahydrofuran (THF) in the re-dissolved into dried MgSO4 along with 2,3-dichloro-5 ,6-dicyano-p-benzoquinone (DDQ) (37.9 g, 136.7 mmol) was stirred for 10 minutes at room temperature the insert. After the reaction was complete, the resultant solution was filtered, and then distilled under reduced pressure. Crude to the product by using Ethyl acetate in Hexane within 0 to 10% as eluent and purified by column chromatography on silica gel solid off-white (50.3 g, yield: 87%; MS: [M + H] + = 422 ) it was obtained.

References:

LG Chemical Co., Ltd.;Kang, Min Young;HAN, Mi Yeon;Lee, Dong Hoon;Hao, Jung Oh;Jang, Poon Jae;Jung, Won Uii;Hao, Dong Wook;Jung, Min Woo KR2016/90262, 2016, A Location in patent:Paragraph 0902-0904