2-chloro-4,6-diphenyl-1,3,5-triazine synthesis
- Product Name:2-chloro-4,6-diphenyl-1,3,5-triazine
- CAS Number:3842-55-5
- Molecular formula:C15H10ClN3
- Molecular Weight:267.71
Yield:3842-55-5 94.1%
Reaction Conditions:
with bis(tricyclohexylphosphine)nickel(II) dichloride;potassium carbonate in tetrahydrofuran at 70; for 12 h;Green chemistry;Friedel-Crafts Alkylation;Reagent/catalyst;Solvent;Temperature;
Steps:
1-4 Example 2
In 500ml reaction flask was added 18.5g (0.1mol)1,3,5-triazine, 26.8 g (0.22 mol) phenylboronic acid,34.5 g (0.25 mol) of potassium carbonate, 1 g of catalyst Ni(pcy3)2Cl2,100g of tetrahydrofuran, stirring and heating to 70 ° C, heat preservation reaction for 12h,Cool to room temperature, and add 100 ml of water to quench the reaction.The solvent is then distilled to recover the solvent tetrahydrofuran.After the tetrahydrofuran fraction is distilled off, the temperature is filtered, and the filter cake is washed to neutrality.Obtained 25.2 g of 2-chloro-4,6-diphenyl-1,3,5-triazine, the yield was 94.1%.The purity was 98.9%, wherein the content of one substituent was 0.28%, and the content of trisubstituted substance was 0.56%.
References:
CN109851569,2019,A Location in patent:Paragraph 0013-0016
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