2-(1-cyclohexen-1-yl)pyridine synthesis
- Product Name:2-(1-cyclohexen-1-yl)pyridine
- CAS Number:14159-55-8
- Molecular formula:C11H13N
- Molecular Weight:159.23
109-09-1
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Yield:14159-55-8 80%
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0);potassium carbonate in tetrahydrofuran at 80; for 12 h;Inert atmosphere;
Steps:
2 2. Synthesis of Ligand L-1
2-bromopyridine (10 g, 88.1 mmol) was added to a three-necked flask under nitrogen.Cyclohexene-1-boronic acid pinacol ester (20.2 g, 96.9 mmol), 2M-potassium carbonate (100 mL) was dissolved in tetrahydrofuran (100 mL). Nitrogen was replaced for 30 minutes, and a catalyst tetrakistriphenylphosphine palladium (3 mol%) was added. The reaction system was heated to 80 ° C,Stirring was carried out for 12 hours. After cooling to room temperature, the reaction was quenched with water, and the mixture was extracted with ethyl acetate and brine. Wash two or three times with saturated saline solution.Take the organic phase. The organic phase was dried over anhydrous magnesium sulfate and concentrated. Separation and purification by silica gel column to obtain ligandL-1 (11.2 g, yield: 80%).
References:
CN109776616,2019,A Location in patent:Paragraph 0081-0083
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