ChemicalBook CAS DataBase List 2,2,2-TRIFLUOROETHYL METHYL ETHER

2,2,2-TRIFLUOROETHYL METHYL ETHER synthesis

11synthesis methods

Product Name:2,2,2-TRIFLUOROETHYL METHYL ETHER
CAS Number:460-43-5
Molecular formula:C3H5F3O
Molecular Weight:114.07

433-06-7
199 suppliers
$9.00/1g

124-41-4 Synthesis

124-41-4
671 suppliers
$12.00/25g

460-43-5
34 suppliers
$40.00/5 g

Yield: 88.6%

Reaction Conditions:

in methanol at 20; for 4 h;

Steps:

1
Weighed 127 g of intermediate p-toluenesulfonic acid-2,2,2-trifluoroethyl ester, 32.5 g of sodium methoxide and 100 ml of methanol in a 500 mL three-necked flask equipped with magnetic stirring and a thermometer, and stirred at 20 ° C. After 4 hours, the progress of the reaction was monitored by gas chromatography. After the reaction was completed, the stirring was stopped, and the reaction liquid was rectified to obtain 50 g of the desired product 2,2,2-trifluoroethyl methyl ether. The purity was 99.8%, and the yield was 88.6%.

References:

Zhejiang Chemical Institute Co., Ltd.;Sinochem Lantian Group Co., Ltd.;Li Wei;Zhang Di;Liu Dongpeng;Guo Zhikai CN109867612, 2019, A Location in patent:Paragraph 0055; 0057