2,2,2-TRIFLUOROETHYL METHYL ETHER synthesis
- Product Name:2,2,2-TRIFLUOROETHYL METHYL ETHER
- CAS Number:460-43-5
- Molecular formula:C3H5F3O
- Molecular Weight:114.07
Yield: 88.6%
Reaction Conditions:
in methanol at 20; for 4 h;
Steps:
1
Weighed 127 g of intermediate p-toluenesulfonic acid-2,2,2-trifluoroethyl ester, 32.5 g of sodium methoxide and 100 ml of methanol in a 500 mL three-necked flask equipped with magnetic stirring and a thermometer, and stirred at 20 ° C. After 4 hours, the progress of the reaction was monitored by gas chromatography. After the reaction was completed, the stirring was stopped, and the reaction liquid was rectified to obtain 50 g of the desired product 2,2,2-trifluoroethyl methyl ether. The purity was 99.8%, and the yield was 88.6%.
References:
Zhejiang Chemical Institute Co., Ltd.;Sinochem Lantian Group Co., Ltd.;Li Wei;Zhang Di;Liu Dongpeng;Guo Zhikai CN109867612, 2019, A Location in patent:Paragraph 0055; 0057
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
