2-(2,3-Dimethylphenyl)acetonitrile synthesis
- Product Name:2-(2,3-Dimethylphenyl)acetonitrile
- CAS Number:76574-43-1
- Molecular formula:C10H11N
- Molecular Weight:145.2
1116-76-3
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74-87-3
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$18.50/48622
140-29-4
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76574-43-1
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Yield:76574-43-1 99%
Reaction Conditions:
with sodium hydroxide in water;
Steps:
1 Preparation of dimethylbenzyl cyanide
EXAMPLE 1 Preparation of dimethylbenzyl cyanide A reactor was charged with 1416 g of sodium hydroxide solution, 33% strength, and 425 g of caustic soda. 6 g of trioctylamine was then added to this solution, and then 400 g of benzyl cyanide and 380 g of chloromethane were reacted in this mixture at from 20° C. to 40° C. with stirring at superatmospheric pressure. After the internal pressure had dropped to below 0.5 bar, the residual pressure was released. 2000 ml of water were then added, and the mixture was briefly stirred and allowed to settle, and then the phases were separated. The organic phase was distilled under reduced pressure to give 485.5 g of pure dimethylbenzyl cyanide having a content of more than 99%, as determined by gas chromatography "GC".
References:
US6143896,2000,A
13651-55-3
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$201.47/1gm:
151-50-8
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76574-43-1
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13651-14-4
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$28.00/1g
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583-71-1
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$13.43/1gm:
75-05-8
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3020-06-2
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76574-43-1
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