ChemicalBook CAS DataBase List 2-(3-NITROPHENOXY)PYRIDINE 97+%

2-(3-NITROPHENOXY)PYRIDINE 97+% synthesis

7synthesis methods

Product Name:2-(3-NITROPHENOXY)PYRIDINE 97+%
CAS Number:28355-48-8
Molecular formula:C11H8N2O3
Molecular Weight:216.19

142-08-5 Synthesis

142-08-5
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402-67-5 Synthesis

402-67-5
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28355-48-8
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Yield:28355-48-8 87%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 125; for 24 h;Inert atmosphere;

Steps:

53.1 Step 1: 2-(3-Nitrovhenoxy)vwidine (53.2)

[00555] A mixture of intermediate 47.1 (1.00 g, 7.09 mmol), intermediate 53.1 (0.81 g, 8.50 mmol), and K2CO3 (1.96 g, 14.17 mmol) in DMF (10 mL) was stirred at 125 °C for 24 h. Once cooled to r.t. the reaction was poured into EtOAc (40 mL), washed with H2O (40 mL), and brine (40 mL), dried over Na2S04, and concentrated under reduced pressure. After chromatographic purification (CLhCh/MeOH from 99:1 to 96:4, v/v), 1.35 g of intermediate 53.2 were obtained. [00556] Yield: 87%. [00557] MS-ESI(+) m/z: 217.3 (M+H).

References:

WO2021/170658,2021,A1 Location in patent:Paragraph 00555-00557

4783-68-0 Synthesis