2,4-Dibromo-1-fluorobenzene synthesis
- Product Name:2,4-Dibromo-1-fluorobenzene
- CAS Number:1435-53-6
- Molecular formula:C6H3Br2F
- Molecular Weight:253.89
146328-85-0
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1435-53-6
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Yield:1435-53-6 89%
Reaction Conditions:
with bromine;dibromoisocyanuric acid in dichloromethane at 60; for 24 h;UV-irradiation;Temperature;
Steps:
6 EXAMPLE 6
EXAMPLE 6 Bromoisocyanurate induced radical bromodecarboxylation of (0335) arenecarboxylic acids bromoisocyanurate (0336) ArCO H ArBr (0337) 2 hv (0338) [00139] A mixture of arenecarboxylic acid ArC02H (1 mmol), bromoisocyanurate, additive and solvent (10 mL) was stirred under fluorescent room light (FL) or warm-white 3 W LED (LL) irradiation (hv). The reaction mixture washed with 1 M aq Na2S03, dried over Na2S04, filtered through short neutral alumina pad and concentrated in vacuo to yield crude bromoarene ArBr. Optionally, the crude bromide was purified by chromatography on silica gel. The results are presented in Table 5.
References:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED;GANDELMAN, Mark;NISNEVICH, Gennady A.;KULBITSKI, Kseniya;ARTARYAN, Alexander WO2017/60905, 2017, A1 Location in patent:Paragraph 00139; 00153
2924-09-6
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1435-53-6
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462-06-6
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1435-53-6
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1493-27-2
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1435-53-6
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462-06-6
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1072-85-1
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1435-53-6
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359-90-0
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460-00-4
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