2,4-Dimethylthiazole synthesis
- Product Name:2,4-Dimethylthiazole
- CAS Number:541-58-2
- Molecular formula:C5H7NS
- Molecular Weight:113.18
Yield:541-58-2 75%
Reaction Conditions:
in N,N-dimethyl-formamide at 60; for 1 h;Sealed tube;Hantzsch Thiazole Synthesis;
Steps:
2.4 4.2.1. Methyl-4-phenylthiazole (1)30
General procedure: Thioamide 0.75 g (10 mmol) and bromoacetophenone 1.99 g (10 mmol) were dissolved 5 mL of DMF in a 20 mL pressure tube. The reaction mixtures were sealed and heated 1 h at 60 °C in oil bath. The resulting mixture was diluted with saturated aqueous ammonium chloride. The product was extracted with ethyl acetate. The ethyl acetate layer was dried over anhydrous magnesium sulfate, filtered, and concentrated. The product was purified by silica gel column chromatography using hexane:ethyl acetate. 2-Methyl-4-phenyl-thiazole was obtained in 99% yield as a white solid.
References:
Kim, Su Kang;Kim, Ji-Hyun;Park, Young Chul;Kim, Jae Won;Yum, Eul Kgun [Tetrahedron,2013,vol. 69,# 51,p. 10990 - 10995]
7208-05-1
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$45.00/10mg
541-58-2
260 suppliers
$6.00/1g
77470-53-2
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$19.00/1g
541-58-2
260 suppliers
$6.00/1g