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ChemicalBook CAS DataBase List 2,5-Difluorobenzoic acid

2,5-Difluorobenzoic acid synthesis

8synthesis methods
2,5-Difluorobenzoic acid can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly in laboratory research and development. It can be synthesized by oxidation reaction of 1,2,4-Trifluorobenzene as raw material .
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: BuLi / tetrahydrofuran / -70 °C
1.2: tetrahydrofuran
2.1: 16 percent Spectr. / Na; NH3 / 0.25 h / -45 °C

References:

Konovalov, Valery V.;Laev, Sergey S.;Beregovaya, Irina V.;Shchegoleva, Lyudmila N.;Shteingarts, Vitalij D.;Tsvetkov, Yuri D.;Bilkis, Itzhak [Journal of Physical Chemistry A,2000,vol. 104,# 2,p. 352 - 361]

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