ChemicalBook CAS DataBase List 2,6-DIMETHYL-3,5-HEPTANEDIONE

2,6-DIMETHYL-3,5-HEPTANEDIONE synthesis

4synthesis methods

Product Name:2,6-DIMETHYL-3,5-HEPTANEDIONE
CAS Number:18362-64-6
Molecular formula:C9H16O2
Molecular Weight:156.22

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97-62-1 Synthesis

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18362-64-6
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Yield:18362-64-6 77.3 %Chromat.

Reaction Conditions:

with potassium tert-butylate in DMF (N,N-dimethyl-formamide) at 50; for 11 h;Heating / reflux;

Steps:

1
In a 1-liter four-necked flask, 103 g of DMF and 1.33mol (149 g) of tert-butoxypotassium were placed, and theywere heated up to 50°C with stirring by a mechanicalstirrer. Then, a liquid mixture consisting of 2.64 mol(307 g) of ethyl isobutyrate and 0.88 mol (75.6 g) of 3-methyl-2-butanone, was added by a dropping funnel over aperiod of 3 hours, followed by further stirring for 8hours under heating. It was confirmed by gaschromatography that 2,6-dimethyl-3,5-heptanedione was produced in an amount of 0.68 mol (107 g) in the solution(yield: 77.3% (based on 3-methylbutanone)).

References:

SHOWA DENKO K.K. WO2004/110971, 2004, A2 Location in patent:Page/Page column 24-25

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