2-Bromo-5-chlorobenzaldehyde synthesis
- Product Name:2-Bromo-5-chlorobenzaldehyde
- CAS Number:174265-12-4
- Molecular formula:C7H4BrClO
- Molecular Weight:219.46
66192-24-3
174265-12-4
Step 2: Synthesis of 2-bromo-5-chlorobenzaldehyde; Preparation was carried out with reference to the literature method (J. Am. Chem. Soc. 2002, 124(7), 1354): a mixture of activated powdered 4A molecular sieves (800 mg/mmol of substrate), N-methylmorpholine-N-oxide (2 eq.) and 2-bromomethyl-5-chlorobenzaldehyde (1 eq.) was stirred for 2 hours at 0°C in a N -methylpyrrolidone (0.16 M) were stirred for 2 hours. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and the filtrate was subsequently concentrated under vacuum to afford the target product 2-bromo-5-chlorobenzaldehyde in 92% yield.
66192-24-3
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174265-12-4
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Yield:174265-12-4 92%
Reaction Conditions:
with 4-methylmorpholine N-oxide in acetonitrile at 0; for 2 h;Molecular sieve;
Steps:
8.2
Step 2: 2-bromo-5-chlorobenzaldehyde; 2-bromo-5-chlorobenzaldehyde was prepared according to literature precedent (/. Am. Chem. Soc. 2002, 124 (7), 1354): a mixture of activated powdered 4A molecular sieves (800 mg/mmol substrate), N- methylmorpholine-N-oxide (2 eq) and 2-bromomethyl-5-chlorobenzaldehyde (1 eq) in MeCN (0.16 M) was stirred at 0 0C for 2 h. The reaction was then filtered through a pad of celite and concentrated in vacuo to afford the title compound (92 %)
References:
WO2006/46030,2006,A2 Location in patent:Page/Page column 28
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