2-Methoxy-1-(4'-trifluoromethyl)phenylethanone synthesis
- Product Name:2-Methoxy-1-(4'-trifluoromethyl)phenylethanone
- CAS Number:26771-69-7
- Molecular formula:C10H9F3O2
- Molecular Weight:218.17
Yield:26771-69-7 > 95 %Chromat.
Reaction Conditions:
in methanol at 20; for 24 h;
Steps:
2 COMPARATIVE EXAMPLE 2
COMPARATIVE EXAMPLE 2 [A PRESSURE-PROOF GLASS VESSEL WAS CHARGED WITH L. 00G (3. 74MMOL, LEQ. )] [OF 2-BROMO-4'-TRIFLUOROMETHYLACETOPHENONE] and 4. 38g of 30% [MEOK] solution containing 18. [74MMOL] (5. [01EQ.)] of [MEOK] dissolved in methanol, followed by stirring for 24hr at room temperature. After the reaction, the reaction liquid was poured into a saturated brine, followed by extraction with ethyl acetate. The collected organic layer was dried with anhydrous sodium sulfate, followed by filtration, concentration and vacuum drying, thereby obtaining 0.94g of a crude product [OF A TRIFLUOROMETHYL-SUBSTITUTED 2-ALKOXYACETOPHENONE] derivative represented by the following formula. As a result of an analysis of the crude product with gas chromatography and [1H-NMR] and 19F-NMR, it was found that the raw material had almost been consumed (conversion>95%). However, the yield was found by a 19F-NMR internal standard method to be less than 5%.
References:
WO2004/14887,2004,A1 Location in patent:Page 27-28
![1,3-Dioxolane, 2-(methoxymethyl)-2-[4-(trifluoromethyl)phenyl]-](/CAS/20180601/GIF/658680-41-2.gif)
658680-41-2
0 suppliers
inquiry
26771-69-7
36 suppliers
inquiry
402-44-8
289 suppliers
$9.00/1g
132289-57-7
44 suppliers
$31.00/250mg
26771-69-7
36 suppliers
inquiry
![2-Propenoic acid, 3-hydroxy-2-methoxy-3-[4-(trifluoromethyl)phenyl]-, methyl ester](/CAS/20210305/GIF/612493-95-5.gif)
612493-95-5
0 suppliers
inquiry
26771-69-7
36 suppliers
inquiry